Journal Articles

This page contains an overview of relevant publications of centre researchers.

Detection of cell-surface phosphatidylserine using the fluorogenic probe P-IID. Meth. Enzymol. (2020) 640, 291-307.

Decarboxylative Couplings for Late-Stage Peptide Modifications. Methods Mol. Biol. (2020) 2103, 275-285.

Venom-derived modulators of epilepsy-related ion channels. Biochem. Pharmacol. (2020) , 114043.

PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease. BMC Mol Cell Biol (2020) 21, 26.

Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display. J. Am. Chem. Soc. (2020) 142, 9141-9146.

Proteome Analysis of Hordein-Null Barley Lines Reveals Storage Protein Synthesis and Compensation Mechanisms. J. Agric. Food Chem. (2020) 68, 5763-5775.

Synthesis of Nitro-Aryl Functionalised 4-Amino-1,8-Naphthalimides and Their Evaluation as Fluorescent Hypoxia Sensors. Chemistry (2020) In Press.

Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria. mSystems (2020) 5, In Press.

Cytokines in the grass, a lesson learnt: Measuring cytokines in plasma using multiple reaction monitoring mass spectrometry. Rapid Commun. Mass Spectrom. (2020) 34, e8723.

Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. J. Biol. Chem. (2020) In Press.

Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualization. EJNMMI Res (2020) 10, 49.

Understanding the early stages of peptide formation during the biosynthesis of teicoplanin and related glycopeptide antibiotics. FEBS J. (2020) In Press.

Identification and Quantitation of Amylase Trypsin Inhibitors Across Cultivars Representing the Diversity of Bread Wheat. J. Proteome Res. (2020) 19, 2136-2148.

Resolving hemocyanin isoform complexity in haemolymph of black tiger shrimp Penaeus monodon – implications in aquaculture, medicine and food safety. J Proteomics (2020) 218, 103689.

A selective NaV1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem. Pharmacol. (2020) , 113991.

Circular Permutation of the Native Enzyme-Mediated Cyclization Position in Cyclotides. ACS Chem. Biol. (2020) 15, 962-969.

Total Synthesis and Antitrypanosomal Activity of Janadolide and Simplified Analogues. Org. Lett. (2020) 22, 3089-3093.

EGF-like and Other Disulfide-rich Microdomains as Therapeutic Scaffolds. Angew. Chem. Int. Ed. Engl. (2020) 59, 11218-11232.

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene. Proc. Natl. Acad. Sci. U.S.A. (2020) 117, 11399-11408.

Studies of the labile lead pool using a rhodamine-based fluorescent probe. Metallomics (2020) 12, 644-648.

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli. PLoS Biol. (2020) 18, e3000644.

Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochem. Pharmacol. (2020) , 114080.

Semisynthesis of an evasin from tick saliva reveals a critical role of tyrosine sulfation for chemokine binding and inhibition. Proc. Natl. Acad. Sci. U.S.A. (2020) 117, 12657-12664.

Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe. Biomedicines (2020) 8, 155.

Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation. J. Med. Chem. (2020) 63, 5956-5971.

Animal toxins – Natures evolutionary-refined toolkit for basic research and drug discovery. Biochem. Pharmacol. (2020) , 114096.

Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold. ACS Chem. Biol. (2020) 15, 1650-1661.

Total Synthesis and Antimycobacterial Activity of Ohmyungsamycin A, Deoxyecumicin, and Ecumicin. Chemistry (2020) In Press.

Critical Residue Properties for Potency and Selectivity of α-Conotoxin RgIA Towards α9α10 Nicotinic Acetylcholine Receptors. Biochem. Pharmacol. (2020) , 114124.

Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species. J. Nat. Prod. (2020) 83, 1817-1828.

A Chemoenzymatic Approach to the Synthesis of Glycopeptide Antibiotic Analogues. Angew. Chem. Int. Ed. Engl. (2020) 59, 10899-10903.

Sunflower Trypsin Inhibitor-1 (SFTI-1): Sowing Seeds in the Fields of Chemistry and Biology. Angew. Chem. Int. Ed. Engl. (2020) In Press.

Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. Angew. Chem. Int. Ed. Engl. (2020) 59, 11273-11277.

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state. Chem. Commun. (Camb.) (2020) 56, 2240-2243.

Strategies for Increasing Protein Stability. Methods Mol. Biol. (2020) 2073, 163-181.

MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1. Cancer Discov (2020) 10, 124-141.

Synthesis and structure-activity relationships of teixobactin. Ann. N. Y. Acad. Sci. (2020) 1459, 86-105.

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. J. Cell. Biochem. (2020) 121, 244-258.

Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens. Mar Drugs (2020) 18, 51.

Peptide Ligation at High Dilution via Reductive Diselenide-Selenoester Ligation. J. Am. Chem. Soc. (2020) 142, 1090-1100.

Activity-Based Sensing: Achieving Chemical Selectivity through Chemical Reactivity. Acc. Chem. Res. (2020) 53, 1.

Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors. J. Med. Chem. (2020) 63, 816-826.

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathog. (2020) 16, e1008287.

Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics. Oncogene (2020) 39, 1167-1184.

Synthesis and Utility of β-Selenophenylalanine and β-Selenoleucine in Diselenide-Selenoester Ligation. J. Org. Chem. (2020) 85, 1567-1578.

Exploring the Tetracyclization of Teicoplanin Precursor Peptides through Chemoenzymatic Synthesis. J. Org. Chem. (2020) 85, 1537-1547.

Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs. ACS Pharmacol Transl Sci (2020) 3, 119-134.

A fluorescent three-sensor array for heavy metals in environmental water sources. Analyst (2020) 145, 1195-1201.

Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7. Biomedicines (2020) 8, 37.

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. J. Biol. Chem. (2020) 295, 5067-5080.

Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2. Cell Rep (2020) 30, 2712-2728.e8.

Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA. J. Med. Chem. (2020) 63, 1564-1575.

Type II Photoinitiator and Tuneable Poly(Ethylene Glycol)-Based Materials Library for Visible Light Photolithography. Tissue Eng Part A (2020) 26, 292-304.

Weaponisation on the fly: Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies. Insect Biochem. Mol. Biol. (2020) 118, 103310.

The unusual conformation of cross-strand disulfide bonds is critical to the stability of β-hairpin peptides. Proteins (2020) 88, 485-502.

NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors. J. Biomol. Struct. Dyn. (2020) 38, 1388-1397.

Structurally Diverse Acyl Bicyclobutanes: Valuable Strained Electrophiles. Chemistry (2020) 26, 2808-2812.

Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell-Wall Precursor Lipid II. Chembiochem (2020) 21, 789-792.

CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation. Nat Commun (2020) 11, 1519.

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nat Commun (2020) 11, 1575.

The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat. Immunol. (2020) 21, 400-411.

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochem. Pharmacol. (2020) 174, 113782.

PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth. BMC Mol Cell Biol (2020) 21, 24.

Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. J. Med. Chem. (2020) 63, 3475-3484.

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation Nature (2019) 566 548–552

The structure and stability of the disulfide-linked γS-crystallin dimer provide insight into oxidation products associated with lens cataract formation. J. Mol. Biol. (2019) 431, 483-497

Anti-microfouling activity of Glycomyces sediminimaris UTMC 2460 on dominant fouling bacteria of Iran marine habitats. Front. Microbiol. (2019) 9, 3148

Complex problems need detailed solutions: harnessing multiple data types to inform genetic management in the wild. Evolutionary Application (2019) 12, 280–291

A fluorogenic probe for cell surface phosphatidylserine using an intramolecular indicator displacement sensing mechanism. Angew Chem Int Ed (2019) 58, 3087-3091

Pattern recognition of toxic metal ions using a single-probe thiocoumarin array. Analyst, (2019) 144, 230-236.

Highly fluorescent and HDAC6 selective scriptaid analogues. European Journal of Medicinal Chemistry, (2019) 162, 321-333

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Lett. (2019)

NaV 1.6 regulates excitability of mechanosensitive sensory neurons. J Physiol. (2019)

Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold. Int J Pharm. (2019) 565 437-446

Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. Br J Pharmacol. (2019)

Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32 Front Microbiol. (2019) 10, 795

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential. ACS Infect Dis. (2019)

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proc Natl Acad Sci U S A. (2019) 116, 7831-7836.

Anchor Residues Guide Form and Function in Grafted Peptides. Angew Chem Int Ed Engl. (2019)

Amino Acid Scanning at P5′ within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases. J Med Chem 2019 62, 3696-3706.

Efficient Enzymatic Cyclization of Disulfide-Rich Peptides by Using Peptide Ligases. Chembiochem. (2019)

Toward Structure Determination of Disulfide-Rich Peptides Using Chemical Shift-Based Methods. J Phys Chem B (2019) 123, 1903-1912.

Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica. J Nat Prod (2019) 82, 293-300.

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins. Structure. (2019) 27, 315-326.

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J Med Chem (2019) 62, 552-560.

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1. ACS Chem Biol (2019) 14, 118-130.

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB J (2019) 33, 3693-3703.

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation. Nature (2019) 566, 548-552.

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1. J Biol Chem. (2019) 294, 3464-3475.

A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α- and β-Glycosylation. Org Lett. (2019) 21, 3584-3588.

Triarabinosylation is required for nodulation-suppressive CLE peptides to systemically inhibit nodulation in Pisum sativum. Plant Cell Environ. (2019) 42, 188-197.

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem. (2019)

Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity. Commun Biol. (2019) 2 99

Fecal Viral Diversity of Captive and Wild Tasmanian Devils Characterized Using Virion-Enriched Metagenomics and Metatranscriptomics. J Virol. (2019) 93 e00205-19.

Too much of a good thing? Finding the most informative genetic data set to answer conservation questions. Mol Ecol Resour. (2019) 19, 659-671.

The spectroelectrochemical behaviour of redox-active manganese salen complexes. Dalton Trans. (2019) 48, 3704-3713.

The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets. Free Radic Biol Med. (2019) 135 157-166.

Bioinspired Small-Molecule Tools for the Imaging of Redox Biology. Acc Chem Res. (2019) 52, 623-632.

Diverse MR1-restricted T cells in mice and humans. Nat Commun. (2019) 10, 2243.

Crystal Structures of Protein-Bound Cyclic Peptides. Chem Rev. (2019)

Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replication. J Virol. (2019) JVI.00239-19.

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis. Clin Exp Pharmacol Physiol. (2019) 46, 456-464.

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques. J Immunol. (2019) 202, 2105-2120.

Structure-Activity Relationships of Wollamide Cyclic Hexapeptides with Activity against Drug-Resistant and Intracellular Mycobacterium tuberculosis. Antimicrob Agents Chemother. (2019) 63, e01773-18.

NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors. J Biomol Struct Dyn. (2019)

Tying pest insects in knots: the deployment of spider-venom-derived knottins as bioinsecticides. Pest Manag Sci. (2019)

A process of convergent amplification and tissue-specific expression dominates the evolution of toxin and toxin-like genes in sea anemones. Mol Ecol. (2019)

The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochem Pharmacol. (2019) 163 381-390.

Tracking conformational changes in calmodulin in vitro, in cell extract, and in cells by EPR distance measurements. Chemphyschem. (2019)

De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease. ACS Med Chem Lett. (2019) 10, 168-174.

Mutant T4 DNA polymerase for easy cloning and mutagenesis. PLoS One. (2019) 14, e0211065

Corrigendum: Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms. Angew Chem Int Ed 2019 58, 1866.

A revised biosynthetic pathway for the cofactor F420 in prokaryotes. Nat Commun. (2019) 10, 1558.

Protein engineering: the potential of remote mutations. Biochem Soc Trans. (2019) 47, 701-711.

Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors. Curr Opin Struct Biol. (2019) 57,31-38.

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes. Elife. (2019) 8, e40789.

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain. Proc Natl Acad Sci U S A. (2019) 116, 2913-2918.

The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila. Insect Biochem Mol Biol. (2019) 106, 10-18.

FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress. J Biol Chem. (2019) 294, 2903-2912.

The Structure and Stability of the Disulfide-Linked γS-Crystallin Dimer Provide Insight into Oxidation Products Associated with Lens Cataract Formation. J Mol Biol. (2019) 431, 483-497.

Studying trans-acting enzymes that target carrier protein-bound amino acids during nonribosomal peptide synthesis. Methods Enzymol. (2019) 617, 113-154.

Pentamycin biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-catalysed installation of the C-14 hydroxyl group. ACS Chem Biol. (2019)

Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria. Nat Microbiol. (2019)4, 996-1005.

Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC. J Am Chem Soc. (2019) 141, 216-222.

Efficient Extraction and Digestion of Gluten Proteins. Methods Mol Biol. (2019) 1871 405-412.

Optimisation of protein extraction for in-depth profiling of the cereal grain proteome. J Proteomics. (2019) 197, 23-33.

Quantitation of seven transmembrane proteins from the DHA biosynthesis pathway in genetically engineered canola by targeted mass spectrometry. Food Chem Toxicol. (2019) 126 313-321.

Targeted proteomics to monitor the extraction efficiency and levels of barley α-amylase trypsin inhibitors that are implicated in non-coeliac gluten sensitivity. J Chromatogr A. (2019) S0021-9673(19)30412-1.

Proteomics reveals the in vitro protein digestibility of seven transmembrane enzymes from the docosahexaenoic acid biosynthesis pathway. Food Chem Toxicol. (2019) S0278-6915(19)30282-0.

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix. Proc Natl Acad Sci U S A. (2019) 201817442.

Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein. Mol Pharm. (2019)

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice. Proc Natl Acad Sci U S A. (2019) 116, 7624-7631.

Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus. PLoS Pathog. (2019) 15, e1007759.

De novo design of tunable, pH-driven conformational changes. Science. 2019 364, 658-664.

Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat Struct Mol Biol. (2019)

Self-Assembling 2D Arrays with de Novo Protein Building Blocks. J Am Chem Soc. (2019)

Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein. Proc Natl Acad Sci U S A. (2019) 116, 6806-6811.

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Cell. (2019) 176, 1420-1431.

What has de novo protein design taught us about protein folding and biophysics? Protein Sci. (2019) 28, 678-683.

A cell-free platform for the prenylation of natural products and application to cannabinoid production. Nat Commun. (2019) 10, 565.

De novo design of potent and selective mimics of IL-2 and IL-15. Nature. (2019) 565, 186-191.

Programmable design of orthogonal protein heterodimers. Nature. (2019) 565 106-111.

Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor. Nat Chem Biol. (2019) 15 598-606.

Exploring of minimal RNA substrate of flexizymes. Chembiochem. (2019)

Flexizyme-catalyzed synthesis of 3′-aminoacyl-NH-tRNAs. Nucleic Acids Res. (2019) 47, e54.

Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges. J Am Chem Soc. (2019) 141,4167-4181.

Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation. Angew Chem Int Ed Engl. (2019) 58, 4880-4885.

Engineering Translation Components Improve Incorporation of Exotic Amino Acids. Int J Mol Sci. (2019) 20, pii: E522.

Ribosomal Synthesis of Backbone-Cyclic Peptides Compatible with In Vitro Display. J Am Chem Soc. (2019) 141 2279-2287.

Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides. J Am Chem Soc. (2019) 141, 758-762.

Corrigendum to “Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A” [Bioorg. Med. Chem. 26/6 (2018) 1225-1231]. Bioorg Med Chem. (2019) 27, 578.

Concepts of Catalysis in Site-Selective Protein Modifications. J Am Chem Soc. (2019)

In-solution enrichment identifies peptide inhibitors of protein-protein interactions. Nat Chem Biol. (2019) 15, 410-418.

Conformational Stabilization and Rapid Labeling of a 29-Residue Peptide by a Small Molecule Reaction Partner. Biochemistry. (2019) 58, 1343-1353.

Affinity-based capture and identification of protein effectors of the growth regulator ppGpp. Nat Chem Biol. (2019) 15, 141-150.

Arylation Chemistry for Bioconjugation. Angew Chem Int Ed. (2019) 58, 4810-4839.

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins. Nat Chem. (2019) 11, 78-85.

Studies on a landscape of perfluoroaromatic-reactive peptides. Org Biomol Chem. (2019) 17, 1862-1868.

Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications. ACS Synth Biol. (2019) 8, 1204-1214.

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease. Elife. 2019 8. e42305.

Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin. Org Biomol Chem. (2019) 17, 822-829.

Investigations into the Mechanism of Action of Sublancin. ACS Infect Dis. (2019) 5, 454-459.

CylA is a sequence-specific protease involved in toxin biosynthesis. J Ind Microbiol Biotechnol. (2019) 46, 537-549.

Cyclooctatetraenes through Valence Isomerization of Cubanes: Scope and Limitations. Chemistry. (2019) 25, 2735-2739.

Cyclooctatetraene: A Bioactive Cubane Paradigm Complement. Chemistry. (2019) 25, 2729-2734.

Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor. Chemistry. (2019) 25, 1451-1455.

Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry J. Am. Chem. Soc. (2018) 140, 13327–13334.

Native Chemical Ligation- Photodesulfurization in Flow. J. Am. Chem. Soc. (2018) 140, 9020-9024.

Native Chemical Ligation in Protein Synthesis and Semi-Synthesis. Chem. Soc. Rev. (2018) 47, 9046-9068

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nat Commun (2018) 9, 2411

Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chem Biol (2018) 13, 2973-2980.

A designer’s guide to the making of macrocycles. Nat Chem Biol (2018) 14, 417-427.

Adaptation and conservation insights from the koala genome. Nature genetics (2018), 50, 1102.

Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing. PloS one, (2018) 13, e0200195

Immunization strategies Producing a humoral igg immune response against Devil Facial Tumor Disease in the Majority of Tasmanian Devils Destined for Wild release. Frontiers in immunology (2018) 9, p.259

Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells. Cell death discovery, (2018) 4, p.19. DP140103260

Characterisation of MHC class I genes in the koala. Immunogenetics, (2018) 70, 125-133

A comparison of pseudoproline substitution effects on cyclisation yield in the total syntheses of segetalins B and G. Pept Sci (2018) 110, e24042

Investigating the effects of structure on sulfate recognition by neutral dipeptide receptors Supramol Chem (2018) 30, 667-673.

The Pseudoproline Approach to Peptide Cyclization Aust. J. Chem. (2018) 71, 723-730

Tailoring the properties of a hypoxia-responsive 1,8-naphthalimide for imaging applications. Organic & Biomolecular Chemistry (2018) 16, 619-624

Expanding the breadth of 4-amino-1,8- naphthalimide photophysical properties through substitution of the naphthalimide core. Chemistry - A European Journal. (2018) 24, 5569-5573.

Fluorescent probes for the simultaneous detection of multiple analytes in biology. Chemical Society Reviews (2018) 47 195-208

Glucuronic acid as a helix-inducing linker in short peptides. Chem Commun (2018) 54 2162 – 2165

Bicyclic helical peptides as dual inhibitors selective for Bcl2A1 and Mcl-1 proteins. J Med Chem (2018) 61, 2962-2972.

Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science (2018) 362, eaau2596

The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens. Nature Communications (2018), 9, 755

Venoms to the rescue: insights into the evolutionary biology of venoms are leading to therapeutic advances. Science (2018) 361, 842–844

Defense peptides engineered from Human platelet factor 4 kill Plasmodium by selective membrane disruption. Cell Chem Biol (2018) 25, 1140-1150

Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], potent antimicrobial peptides from rattlesnake venom. J Biol Chem (2018) 293, 1536-1549

Small neutral Gd3+ tags for distance measurements in proteins by double electron–electron resonance experiments. Phys. Chem. Chem. Phys. (2018) 20, 23535-23545

Accurate electron–nucleus distances from paramagnetic relaxation enhancements. J. Am. Chem. Soc. (2018) 140, 7688-7697

Site-specific incorporation of selenocysteine by genetic encoding as a photocaged unnatural amino acid. Bioconjugate Chem. (2018) 29, 2257- 2264

Two histidines in an α-helix: rigid Co2+–binding motif for PCS measurements by NMR spectroscopy. Angew. Chemie Int. Ed. (2018) 57, 6226-6229.

Small Gd(III) tags for Gd(III)-Gd(III) distance measurements in proteins by EPR spectroscopy. Inorg. Chem. (2018) 57, 5048-5059

Peptide Modification and Cyclization via Transition-Metal Catalysis. Curr. Opin. Chem. Biol. (2018) 46, 25-32

Decarboxylative Couplings as Versatile Tools for Late-Stage Peptide Modifications. Peptide Science (2018) 110 :e24049

The evolution of multiple active site configurations in a designed enzyme. Nature Comm. (2018) 9, 3900

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS. Nature Chem. Biol. (2018) 14, 861

Hydrogel-immobilized supercharged proteins. Adv. Biosystems. (2018) 2, 1700240

Evolution of an enzyme from a solute binding protein. Nature Chem. Biol. (2018) 14, 542

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis Chem. Sci. (2018) 10, 118-133

The many faces and important roles of protein-protein interactions during non-ribosomal peptide synthesis Nat. Prod. Rep. (2018) 35, 1120-1139

Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach. J. Inorg. Biochem. (2018) 185, 43-51.

Precursor Manipulation in Glycopeptide Antibiotic Biosynthesis: Are β-Amino Acids Compatible with the Oxidative Cyclization Cascade? J. Org. Chem. (2018) 83, 7206–7214

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism Nat. Prod. Rep. (2018) 35, 757-791.

Desferrioxamine Biosynthesis: diverse hydroxamate assembly by substrate tolerant acyl transferase DesC. Phil. Trans. Royal Soc. B (2018) 373, 20170068

Discovery and characterisation of cyclotides from Rinorea species. Journal of Natural Products (2018) 81 2512–2520

Oat of this world: Defining peptide markers for detection of oats in processed food. Biopolymers Peptide Science (2018) 110 e24045

Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure. Nat Methods. (2018) 15, 1029-1032

Nanobody-Antigen Conjugates Elicit HPV- Specific Antitumor Immune Responses. Cancer Immunol Res. (2018) 6, 870-880

Sortase A: A Model for Transpeptidation and Its Biological Applications. Annu Rev Cell Dev Biol. (2018) 34 163-188

Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chem Biol. (2018) 3, 2973-2980

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Bioconjug Chem. (2018) 29, 3245-3249.

Protein homology model refinement by large-scale energy optimization. Proc Natl Acad Sci U S A (2018) 115, 3054-3059

Structures and disulfide cross-linking of de novo designed therapeutic mini-proteins. FEBS J. (2018) 285, 1783-1785

Nonproteinogenic deep mutational scanning of linear and cyclic peptides. Proceedings of the National Academy of Sciences USA (2018) 115, 10959-10964

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