Journal Articles

This page contains an overview of relevant publications of centre researchers.

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation Nature (2019) 566 548–552

The structure and stability of the disulfide-linked γS-crystallin dimer provide insight into oxidation products associated with lens cataract formation. J. Mol. Biol. (2019) 431, 483-497

Anti-microfouling activity of Glycomyces sediminimaris UTMC 2460 on dominant fouling bacteria of Iran marine habitats. Front. Microbiol. (2019) 9, 3148

Complex problems need detailed solutions: harnessing multiple data types to inform genetic management in the wild. Evolutionary Application (2019) 12, 280–291

A fluorogenic probe for cell surface phosphatidylserine using an intramolecular indicator displacement sensing mechanism. Angew Chem Int Ed (2019) 58, 3087-3091

Pattern recognition of toxic metal ions using a single-probe thiocoumarin array. Analyst, (2019) 144, 230-236.

Highly fluorescent and HDAC6 selective scriptaid analogues. European Journal of Medicinal Chemistry, (2019) 162, 321-333

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Lett. (2019)

NaV 1.6 regulates excitability of mechanosensitive sensory neurons. J Physiol. (2019)

Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold. Int J Pharm. (2019) 565 437-446

Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. Br J Pharmacol. (2019)

Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32 Front Microbiol. (2019) 10, 795

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential. ACS Infect Dis. (2019)

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proc Natl Acad Sci U S A. (2019) 116, 7831-7836.

Anchor Residues Guide Form and Function in Grafted Peptides. Angew Chem Int Ed Engl. (2019)

Amino Acid Scanning at P5′ within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases. J Med Chem 2019 62, 3696-3706.

Efficient Enzymatic Cyclization of Disulfide-Rich Peptides by Using Peptide Ligases. Chembiochem. (2019)

Toward Structure Determination of Disulfide-Rich Peptides Using Chemical Shift-Based Methods. J Phys Chem B (2019) 123, 1903-1912.

Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica. J Nat Prod (2019) 82, 293-300.

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins. Structure. (2019) 27, 315-326.

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J Med Chem (2019) 62, 552-560.

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1. ACS Chem Biol (2019) 14, 118-130.

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. FASEB J (2019) 33, 3693-3703.

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation. Nature (2019) 566, 548-552.

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1. J Biol Chem. (2019) 294, 3464-3475.

A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α- and β-Glycosylation. Org Lett. (2019) 21, 3584-3588.

Triarabinosylation is required for nodulation-suppressive CLE peptides to systemically inhibit nodulation in Pisum sativum. Plant Cell Environ. (2019) 42, 188-197.

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem. (2019)

Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity. Commun Biol. (2019) 2 99

Fecal Viral Diversity of Captive and Wild Tasmanian Devils Characterized Using Virion-Enriched Metagenomics and Metatranscriptomics. J Virol. (2019) 93 e00205-19.

Too much of a good thing? Finding the most informative genetic data set to answer conservation questions. Mol Ecol Resour. (2019) 19, 659-671.

The spectroelectrochemical behaviour of redox-active manganese salen complexes. Dalton Trans. (2019) 48, 3704-3713.

The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets. Free Radic Biol Med. (2019) 135 157-166.

Bioinspired Small-Molecule Tools for the Imaging of Redox Biology. Acc Chem Res. (2019) 52, 623-632.

Diverse MR1-restricted T cells in mice and humans. Nat Commun. (2019) 10, 2243.

Crystal Structures of Protein-Bound Cyclic Peptides. Chem Rev. (2019)

Oxazole-benzenesulfonamide derivatives inhibit HIV-1 reverse transcriptase interaction with cellular eEF1A and reduce viral replication. J Virol. (2019) JVI.00239-19.

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis. Clin Exp Pharmacol Physiol. (2019) 46, 456-464.

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques. J Immunol. (2019) 202, 2105-2120.

Structure-Activity Relationships of Wollamide Cyclic Hexapeptides with Activity against Drug-Resistant and Intracellular Mycobacterium tuberculosis. Antimicrob Agents Chemother. (2019) 63, e01773-18.

NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors. J Biomol Struct Dyn. (2019)

Tying pest insects in knots: the deployment of spider-venom-derived knottins as bioinsecticides. Pest Manag Sci. (2019)

A process of convergent amplification and tissue-specific expression dominates the evolution of toxin and toxin-like genes in sea anemones. Mol Ecol. (2019)

The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analogues. Biochem Pharmacol. (2019) 163 381-390.

Tracking conformational changes in calmodulin in vitro, in cell extract, and in cells by EPR distance measurements. Chemphyschem. (2019)

De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease. ACS Med Chem Lett. (2019) 10, 168-174.

Mutant T4 DNA polymerase for easy cloning and mutagenesis. PLoS One. (2019) 14, e0211065

Corrigendum: Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms. Angew Chem Int Ed 2019 58, 1866.

A revised biosynthetic pathway for the cofactor F420 in prokaryotes. Nat Commun. (2019) 10, 1558.

Protein engineering: the potential of remote mutations. Biochem Soc Trans. (2019) 47, 701-711.

Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors. Curr Opin Struct Biol. (2019) 57,31-38.

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes. Elife. (2019) 8, e40789.

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain. Proc Natl Acad Sci U S A. (2019) 116, 2913-2918.

The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila. Insect Biochem Mol Biol. (2019) 106, 10-18.

FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress. J Biol Chem. (2019) 294, 2903-2912.

The Structure and Stability of the Disulfide-Linked γS-Crystallin Dimer Provide Insight into Oxidation Products Associated with Lens Cataract Formation. J Mol Biol. (2019) 431, 483-497.

Studying trans-acting enzymes that target carrier protein-bound amino acids during nonribosomal peptide synthesis. Methods Enzymol. (2019) 617, 113-154.

Pentamycin biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-catalysed installation of the C-14 hydroxyl group. ACS Chem Biol. (2019)

Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria. Nat Microbiol. (2019)4, 996-1005.

Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC. J Am Chem Soc. (2019) 141, 216-222.

Efficient Extraction and Digestion of Gluten Proteins. Methods Mol Biol. (2019) 1871 405-412.

Optimisation of protein extraction for in-depth profiling of the cereal grain proteome. J Proteomics. (2019) 197, 23-33.

Quantitation of seven transmembrane proteins from the DHA biosynthesis pathway in genetically engineered canola by targeted mass spectrometry. Food Chem Toxicol. (2019) 126 313-321.

Targeted proteomics to monitor the extraction efficiency and levels of barley α-amylase trypsin inhibitors that are implicated in non-coeliac gluten sensitivity. J Chromatogr A. (2019) S0021-9673(19)30412-1.

Proteomics reveals the in vitro protein digestibility of seven transmembrane enzymes from the docosahexaenoic acid biosynthesis pathway. Food Chem Toxicol. (2019) S0278-6915(19)30282-0.

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix. Proc Natl Acad Sci U S A. (2019) 201817442.

Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein. Mol Pharm. (2019)

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice. Proc Natl Acad Sci U S A. (2019) 116, 7624-7631.

Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus. PLoS Pathog. (2019) 15, e1007759.

De novo design of tunable, pH-driven conformational changes. Science. 2019 364, 658-664.

Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat Struct Mol Biol. (2019)

Self-Assembling 2D Arrays with de Novo Protein Building Blocks. J Am Chem Soc. (2019)

Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein. Proc Natl Acad Sci U S A. (2019) 116, 6806-6811.

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Cell. (2019) 176, 1420-1431.

What has de novo protein design taught us about protein folding and biophysics? Protein Sci. (2019) 28, 678-683.

A cell-free platform for the prenylation of natural products and application to cannabinoid production. Nat Commun. (2019) 10, 565.

De novo design of potent and selective mimics of IL-2 and IL-15. Nature. (2019) 565, 186-191.

Programmable design of orthogonal protein heterodimers. Nature. (2019) 565 106-111.

Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor. Nat Chem Biol. (2019) 15 598-606.

Exploring of minimal RNA substrate of flexizymes. Chembiochem. (2019)

Flexizyme-catalyzed synthesis of 3′-aminoacyl-NH-tRNAs. Nucleic Acids Res. (2019) 47, e54.

Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges. J Am Chem Soc. (2019) 141,4167-4181.

Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation. Angew Chem Int Ed Engl. (2019) 58, 4880-4885.

Engineering Translation Components Improve Incorporation of Exotic Amino Acids. Int J Mol Sci. (2019) 20, pii: E522.

Ribosomal Synthesis of Backbone-Cyclic Peptides Compatible with In Vitro Display. J Am Chem Soc. (2019) 141 2279-2287.

Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides. J Am Chem Soc. (2019) 141, 758-762.

Corrigendum to “Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A” [Bioorg. Med. Chem. 26/6 (2018) 1225-1231]. Bioorg Med Chem. (2019) 27, 578.

Concepts of Catalysis in Site-Selective Protein Modifications. J Am Chem Soc. (2019)

In-solution enrichment identifies peptide inhibitors of protein-protein interactions. Nat Chem Biol. (2019) 15, 410-418.

Conformational Stabilization and Rapid Labeling of a 29-Residue Peptide by a Small Molecule Reaction Partner. Biochemistry. (2019) 58, 1343-1353.

Affinity-based capture and identification of protein effectors of the growth regulator ppGpp. Nat Chem Biol. (2019) 15, 141-150.

Arylation Chemistry for Bioconjugation. Angew Chem Int Ed. (2019) 58, 4810-4839.

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins. Nat Chem. (2019) 11, 78-85.

Studies on a landscape of perfluoroaromatic-reactive peptides. Org Biomol Chem. (2019) 17, 1862-1868.

Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications. ACS Synth Biol. (2019) 8, 1204-1214.

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease. Elife. 2019 8. e42305.

Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin. Org Biomol Chem. (2019) 17, 822-829.

Investigations into the Mechanism of Action of Sublancin. ACS Infect Dis. (2019) 5, 454-459.

CylA is a sequence-specific protease involved in toxin biosynthesis. J Ind Microbiol Biotechnol. (2019) 46, 537-549.

Cyclooctatetraenes through Valence Isomerization of Cubanes: Scope and Limitations. Chemistry. (2019) 25, 2735-2739.

Cyclooctatetraene: A Bioactive Cubane Paradigm Complement. Chemistry. (2019) 25, 2729-2734.

Synthesis of the seco-Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor. Chemistry. (2019) 25, 1451-1455.

Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry J. Am. Chem. Soc. (2018) 140, 13327–13334.

Native Chemical Ligation- Photodesulfurization in Flow. J. Am. Chem. Soc. (2018) 140, 9020-9024.

Native Chemical Ligation in Protein Synthesis and Semi-Synthesis. Chem. Soc. Rev. (2018) 47, 9046-9068

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nat Commun (2018) 9, 2411

Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chem Biol (2018) 13, 2973-2980.

A designer’s guide to the making of macrocycles. Nat Chem Biol (2018) 14, 417-427.

Adaptation and conservation insights from the koala genome. Nature genetics (2018), 50, 1102.

Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing. PloS one, (2018) 13, e0200195

Immunization strategies Producing a humoral igg immune response against Devil Facial Tumor Disease in the Majority of Tasmanian Devils Destined for Wild release. Frontiers in immunology (2018) 9, p.259

Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells. Cell death discovery, (2018) 4, p.19. DP140103260

Characterisation of MHC class I genes in the koala. Immunogenetics, (2018) 70, 125-133

A comparison of pseudoproline substitution effects on cyclisation yield in the total syntheses of segetalins B and G. Pept Sci (2018) 110, e24042

Investigating the effects of structure on sulfate recognition by neutral dipeptide receptors Supramol Chem (2018) 30, 667-673.

The Pseudoproline Approach to Peptide Cyclization Aust. J. Chem. (2018) 71, 723-730

Tailoring the properties of a hypoxia-responsive 1,8-naphthalimide for imaging applications. Organic & Biomolecular Chemistry (2018) 16, 619-624

Expanding the breadth of 4-amino-1,8- naphthalimide photophysical properties through substitution of the naphthalimide core. Chemistry - A European Journal. (2018) 24, 5569-5573.

Fluorescent probes for the simultaneous detection of multiple analytes in biology. Chemical Society Reviews (2018) 47 195-208

Glucuronic acid as a helix-inducing linker in short peptides. Chem Commun (2018) 54 2162 – 2165

Bicyclic helical peptides as dual inhibitors selective for Bcl2A1 and Mcl-1 proteins. J Med Chem (2018) 61, 2962-2972.

Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science (2018) 362, eaau2596

The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens. Nature Communications (2018), 9, 755

Venoms to the rescue: insights into the evolutionary biology of venoms are leading to therapeutic advances. Science (2018) 361, 842–844

Defense peptides engineered from Human platelet factor 4 kill Plasmodium by selective membrane disruption. Cell Chem Biol (2018) 25, 1140-1150

Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], potent antimicrobial peptides from rattlesnake venom. J Biol Chem (2018) 293, 1536-1549

Small neutral Gd3+ tags for distance measurements in proteins by double electron–electron resonance experiments. Phys. Chem. Chem. Phys. (2018) 20, 23535-23545

Accurate electron–nucleus distances from paramagnetic relaxation enhancements. J. Am. Chem. Soc. (2018) 140, 7688-7697

Site-specific incorporation of selenocysteine by genetic encoding as a photocaged unnatural amino acid. Bioconjugate Chem. (2018) 29, 2257- 2264

Two histidines in an α-helix: rigid Co2+–binding motif for PCS measurements by NMR spectroscopy. Angew. Chemie Int. Ed. (2018) 57, 6226-6229.

Small Gd(III) tags for Gd(III)-Gd(III) distance measurements in proteins by EPR spectroscopy. Inorg. Chem. (2018) 57, 5048-5059

Peptide Modification and Cyclization via Transition-Metal Catalysis. Curr. Opin. Chem. Biol. (2018) 46, 25-32

Decarboxylative Couplings as Versatile Tools for Late-Stage Peptide Modifications. Peptide Science (2018) 110 :e24049

The evolution of multiple active site configurations in a designed enzyme. Nature Comm. (2018) 9, 3900

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS. Nature Chem. Biol. (2018) 14, 861

Hydrogel-immobilized supercharged proteins. Adv. Biosystems. (2018) 2, 1700240

Evolution of an enzyme from a solute binding protein. Nature Chem. Biol. (2018) 14, 542

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis Chem. Sci. (2018) 10, 118-133

The many faces and important roles of protein-protein interactions during non-ribosomal peptide synthesis Nat. Prod. Rep. (2018) 35, 1120-1139

Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach. J. Inorg. Biochem. (2018) 185, 43-51.

Precursor Manipulation in Glycopeptide Antibiotic Biosynthesis: Are β-Amino Acids Compatible with the Oxidative Cyclization Cascade? J. Org. Chem. (2018) 83, 7206–7214

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism Nat. Prod. Rep. (2018) 35, 757-791.

Desferrioxamine Biosynthesis: diverse hydroxamate assembly by substrate tolerant acyl transferase DesC. Phil. Trans. Royal Soc. B (2018) 373, 20170068

Discovery and characterisation of cyclotides from Rinorea species. Journal of Natural Products (2018) 81 2512–2520

Oat of this world: Defining peptide markers for detection of oats in processed food. Biopolymers Peptide Science (2018) 110 e24045

Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure. Nat Methods. (2018) 15, 1029-1032

Nanobody-Antigen Conjugates Elicit HPV- Specific Antitumor Immune Responses. Cancer Immunol Res. (2018) 6, 870-880

Sortase A: A Model for Transpeptidation and Its Biological Applications. Annu Rev Cell Dev Biol. (2018) 34 163-188

Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chem Biol. (2018) 3, 2973-2980

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1. Bioconjug Chem. (2018) 29, 3245-3249.

Protein homology model refinement by large-scale energy optimization. Proc Natl Acad Sci U S A (2018) 115, 3054-3059

Structures and disulfide cross-linking of de novo designed therapeutic mini-proteins. FEBS J. (2018) 285, 1783-1785

Nonproteinogenic deep mutational scanning of linear and cyclic peptides. Proceedings of the National Academy of Sciences USA (2018) 115, 10959-10964

Display selection of exotic macrocyclic peptides expressed under 23 amino acids reprogrammed genetic code. Journal of the American Chemical Society (2018) 140, 11551-11555

Genetic code expansion via integration of redundant amino acid assignment by finely tuned tRNA pools. Current Opinion Chemical Biology (2018) 46, 212-218

Ribosomal synthesis and folding of peptide-helical aromatic foldamer hybrids. Nature Chemistry (2018) 10, 405–412

Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A. Bioorganic & Medicinal Chemistry (2018) 26, 1225-1231

Artificial division of codon boxes for expansion of the amino acid repertoire of ribosomal polypeptide synthesis. Methods Molecular Biology (2018) 1728, 17-47

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta. J Exp Bot (2018) 69, 633-641

The E15R point mutation in scorpion toxin Cn2 uncouples its depressant and excitatory activities on human Nav1.6. J Med Chem (2018) 61, 1730-1736

Conformational flexibility is a determinant of permeability for cyclosporin. J Phys Chem B (2018) 122, 2261-2276

Development of novel melanocortin receptor agonists based on the cyclic peptide framework of sunflower trypsin inhibitor-1. J Med Chem (2018) 61, 3674-3684

Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-gated calcium channels by α-conotoxin Vc1.1. ACS Chemical Biology (2018) 13, 1577-1587

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology (2018) 155, 288-297.

Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. Br J Pharmacol (2018) 175, 2384- 2398

Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes. J Biol Chem (2018) 293, 9041-9052

Calcium-mediated allostery of the EGF fold. ACS Chem Biol (2018) 13, 1659-1667

CLE peptide tri-arabinosylation and peptide domain sequence composition are essential for SUNN-dependent autoregulation of nodulation in Medicago truncatula. New Phytologist (2018) 218, 73-80

Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection. Chem. Sci. (2018) 9, 896-903.

Rapid and Efficient Protein Synthesis Through Expansion of the Native Chemical Ligation Concept. Nature Rev. Chem. (2018) 2, 0

Mosquito-Derived Anophelin Sulfoproteins are Potent Anti-thrombotics ACS Central Science (2018) 4, 468-476

Triarabinosylation is required for nodulation-suppressive CLE peptides to systemically inhibit nodulation in Pisum sativum. Plant Cell Environ. (2018)

Synthetic Studies Towards the Skyllamycins: Total Synthesis and Generation of Simplified Analogues. J. Org. Chem. (2018) 83, 7250-7270.

Native Chemical Ligation- Photodesulfurization in Flow. J. Am. Chem. Soc. (2018) 140, 9020-9024.

Synthesis and evaluation of analogues of the glycinocin family of calcium-dependent antibiotics. Org. Biomol. Chem. (2018) 16, 5310-5320

A Comprehensive Portrait of the Venom of the Giant Red Bull Ant, Myrmecia gulosa, Reveals a Hyperdiverse Hymenopteran Toxin Gene Family. Science Adv. (2018) 4, eaau4640

Synthesis of a Self-adjuvanting MUC1 Vaccine via Diselenide-Selenoester Ligation-Deselenization. ACS Chem. Biol. (2018)

The effects of group versus intensive housing on the retention of genetic diversity in insurance populations. BMC Zoology, (2018) 3, 2

Founder relationships and conservation management: empirical kinships reveal the effect on breeding programs when founders are assumed to be unrelated. Animal Conservation (2018)

Devil Women. Pacific Conservation Biology (2018) 24, 271-279

Disentangling the mechanisms of mate choice in a captive koala population. PeerJ, (2018) 6, e5438

Landscape-level field data reveal broad- scale effects of a fatal, transmissible cancer on population ecology of the Tasmanian devil. Mammalian Biology, (2018) 91, 41-45

Devil Facial Tumor Disease, A Potential Model of the Cancer Stem-Cell Process?. J Vet, (2018) 1, 43-49.

Are any populations ‘safe’? Unexpected reproductive decline in a population of Tasmanian devils free of devil facial tumour disease. Wildlife Research, (2018) 45, 31-37.

Pedigree reconstruction using molecular data reveals an early warning sign of gene diversity loss in an island population of Tasmanian devils (Sarcophilus harrisii). Conservation Genetics, (2018) 19, 439-450.

MHC diversity and female age underpin reproductive success in an Australian icon; the Tasmanian Devil. Scientific reports, (2018) 8, 4175.

Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo. Scientific reports, (2018) 8, 2412.

Koala immunology and infectious diseases: How much can the koala bare? Developmental & Comparative Immunology. (2018) 82, 177-185.

A Tasmanian devil breeding program to support wild recovery. Reproduction, Fertility and Development. (2018)

Characterisation of the faecal virome of captive and wild Tasmanian devils using virus-like particles metagenomics and meta-transcriptomics. bioRxiv (2018) 443457

Lessons learnt from the Tasmanian devil facial tumour regarding immune function in cancer. Mammalian Genome, (2018) 1-8.

Electroactive Co(III) Salen Metal Complexes and the Electrophoretic Deposition of their Porous Organic Polymers to Glassy Carbon, RSC Advances, (2018) 8, 24128-24142.

Synthesis and Evaluation of a Series of Bis(4-pentylpyridinium) alkanes as Antifungal Agents, Chem Med Chem, (2018) 13, 1421-1436.

Cyclic peptide-poly(HPMA) nanotubes as drug delivery vectors: in vitro assessment, pharmacokinetics and biodistribution. Biomaterials (2018) 178, 570-582.

Secondary self-assembly of supramolecular nanotubes into tubisomes and their activity on cells. Angew Chem Int Ed (2018) 57, 16678-16682

Deltamides and croconamides: Expanding the range of dual H-bond donors for selective anion recognition. Chem Eur J (2018) 24, 1140- 1150.

Cyclic peptide-polymer nanotubes as efficient and highly potent drug delivery systems for organometallic anticancer complexes Biomacromolecules (2018) 19, 239–247.

A fluorescent ditopic rotaxane ion-pair host. Angew. Chem. Int. Ed., (2018) 57, 5315-5319.

Drawing on biology to inspire molecular design: a redox-responsive MRI probe based on Gd(III)-nicotinamide. Chemical Communications, (2018) 54, 12986-12989

A reversible fluorescent probe for monitoring Ag(I) ions. Journal of the Royal Society Interface, (2018) 15

Pro-fluorescent mitochondria-targeted real- time responsive redox probes synthesised from carboxy isoindoline nitroxides: Sensitive probes of mitochondrial redox status in cells. Free Radicals in Biology and Medicine (2018) 128 97-

A ratiometric iron probe enables investigation of iron distribution within tumour spheroids. Metallomics (2018) 10, 553-556.

Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids. Polymer Chemistry (2018) 9 3461-3465

Harnessing the properties of cobalt coordination complexes for biological application. Coordination Chemistry Reviews. (2018) 375, 221-233.

A fluorescent probe for investigating metabolic stability of active transplatin analogues. Sensors and Actuators B-Chemical. (2018) 255 2721-4

Promises and Pitfalls of Metal Imaging in Biology. Cell Chemical Biology. (2018) 25 7-18

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability. Org Biomol Chem (2018) 16, 367-371.

Lysine deacetylases and regulated glycolysis in macrophages. Trends in Immunology (2018) 39, 473-488.

Mucosal-associated invariant T cells augment immunopathology and gastritis Helicobacter pylori infection. J Immunol (2018) 200, 1901-1916.

A potent antagonist of protease-activated receptor 2 that inhibits multiple signalling functions in human cancer cells. J Pharmacol Exp Ther (2018) 364, 246-257.

Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells. JCI Insight (2018) 3, 121697

Hepatic expression profiling by RNA sequencing identifies genes associated with steatosis-independent and steatosis-driven advanced fibrosis.

MAIT cells protect against pulmonary Legionella longbeachae infection. Nature Communications (2018) 9, 3350.

Recipient Mucosal-Associated Invariant T Cells control GVHD within the colon. J Clin Invest (2018) 128, 1919-1936.

Chemically diverse helix-constrained peptides using selenocysteine crosslinking. Org Lett (2018) 20, 1453-1456.

Chemical approaches to modulating complement-mediated disease. J Med Chem (2018) 61, 3253-3276.

Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II. ACS Med Chem Lett (2018) 9, 1258-1262.

Buzz Kill: Function and Proteomic Composition of Venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae). Toxins (Basel). 2018 10, E456.

Total Synthesis of Suillusin. Org Lett. (2018) 20, 7304-7307.

Functional and informatics analysis enables glycosyltransferase activity prediction. Nat Chem Biol. (2018) 14, 1109-1117.

A selective NaV1.1 activator rescues Dravet syndrome mice from seizures and premature death. Proceedings of the National Academy of Sciences USA (2018) 115, E8077–E8085.

ArachnoServer 3.0: an online resource for automated analysis of venom-gland transcriptomes and discovery and annotation of spider toxins. Bioinformatics (2018) 34, 1074–1076.

Giant fish-killer water bug reveals ancient evolution of venom in heteropteran insects. Cellular & Molecular Life Sciences (2018) 75, 3215– 3229.

Inhibition of acid- sensing ion channels by diminazene and APETx2 evokes partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology (2018) 175, 2204–2218.

NaV1.1 inhibition can reduce visceral hypersensitivity. JCI Insight (2018) 3, e121000.

Gomesin inhibits melanoma growth by manipulating signalling cascades that control cell death and proliferation. Scientific Reports (2018) 8, 11519.

Venom-derived inhibitors of the human EAG channel, a novel antiepileptic drug target. Biochemical Pharmacology (2018) 158, 60–72.

Entomo-venomics: evolution, biology, and biochemistry of insect venoms. Toxicon (2018) 154, 15–27.

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold. Cellular & Molecular Life Sciences (2018) 75, 4511–4524.

Evaluation of chemical strategies for improving the stability and oral toxicity of insecticidal peptides. Biomedicines (2018) 6, 90

Dipteran toxicity assays for determining the oral insecticidal activity of venoms and toxins. Toxicon (2018) 150, 297–303.

Efficient enzymatic ligation of inhibitor cystine knot spider-venom peptides: using sortase to form double knottins. Bioconjugate Chemistry (2018) 29, 3309– 331.

Harvesting venom toxins from assassin bugs and other heteropteran insects. Journal of Visualized Experiments (2018) 134, e5772.

Buzz kill: function and proteomic composition of venom from the giant assassin fly Dolopus genitalis (Diptera: Asilidae). Toxins (2018) 10, 456

Molecular characterization and functional identification of invertase inhibitor genes (ShINH1 and ShINH2) from sugarcane. Frontiers in Plant Science (2018) 9, 598.

NMR studies of ligand binding. Curr. Opin. Struct. Biol. (2018) 48, 16-22.

Genetically encoded amino acids with tert-butyl and trimethylsilyl groups for site-selective studies of proteins by NMR spectroscopy. J. Biomol. NMR (2018) 1, 287-293.

Using tert-butyl groups in a ligand to identify its binding site on a protein. ACS Med. Chem. Lett. (2018) 9, 109-113.

Trimethylsilyl tag for probing protein-ligand interactions by NMR. J. Biomol. NMR (2018) 70, 211-218.

Fragment-based discovery of inhibitors of the bacterial DnaG–SSB interaction. Antibiotics (2018) 7, 14.

Conversion of an amide to a high-energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium. Sci. Rep. (2018) 8, 16371.

Laboratory evolution of protein conformational dynamics. Curr. Opin. Struct. Biol. (2018) 50, 49-57.

Evolution of an enzyme from a solute binding protein. Nature Chem. Biol. (2018) 14, 542.

An integrative analysis of non-coding regulatory DNA variations associated with autism spectrum disorder. Mol. Psychiatry. (2018)

An enhanced chemo-enzymatic method for loading substrates onto carrier protein domains, Biochem. Cell Biol. (2018) 96, 372-379.

The Thioesterase Domain in Glycopeptide Antibiotic Biosynthesis Is Selective for Cross-Linked Aglycones, ACS Chem. Biol. (2018) 13, 110-120.

Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors. Nature Chem. (2017) 9, 909-917.

Accelerated Protein Synthesis via One-Pot Ligation–Deselenization Chemistry. Chem. (2017) 2, 703–715.

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. J Biol Chem (2017) 292, 17101-12.

Cyclotides as tools in chemical biology. Acc Chem Res (2017) 50, 1557-1565.

Mitochondrially targeted fluorescent redox sensors. Interface Focus (2017) 7

Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells. Journal of Biological Inorganic Chemistry (2017) 22 765-74

Europium-labeled synthetic C3a protein as a novel fluorescent probe for human complement C3a receptor. Bioconjugate Chem (2017) 28, 1669-1676

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications (2017) 8, 351

Orally absorbed cyclic peptides. Chemical Reviews (2017) 117, 8094-8128

Potent neuroprotection after stroke afforded by a double-knot spider toxin that inhibits acid-sensing ion channel 1a. Proceedings of the National Academy of Sciences USA (2017) 114, 3750–3755.

Redesigned spider peptide with improved antimicrobial and anticancer properties ACS Chem Biol (2017) 12, 2324-2334

New potent membrane-targeting antibacterial peptides from viral capsid proteins Front Microbiol (2017) 8, 775

CITU: A Peptide and Decarboxylative Coupling Reagent. Org. Lett. (2017) 19, 6196-6199

Residue-Specific Peptide Modification. Biochemistry (2017) 56, 3863-3873

Decarboxylative Alkynylation. Angew. Chem. Int. Ed. (2017) 56, 11906-11910.

In vitro biosynthetic studies of bottromycin expand the enzymatic capabilities of the YcaO superfamily. J. Am. Chem. Soc. (2017) 139, 18154-18157

Antibiotics from Gram-negative bacteria: A comprehensive overview and selected biosynthetic highlights. Nat. Prod. Rep. (2017) 34, 712-783

Transcriptome of Brachypodium during fungal pathogen infection reveals both shared and distinct defense responses with wheat. Scientific Reports (2017) 7, 17212

Understanding the diversity and distribution of cyclotides from plants of varied genetic origin. Journal of Natural Products (2017) 80 1522-1530

The Fusarium crown rot pathogen triggers a suite of transcriptional and metabolic changes in wheat (Triticum aestivum). Annals of Botany (2017) 119, 853-867

Comprehensive computational design of ordered peptide macrocycles. Science (2017) 358, 1461-1466

Massively parallel de novo protein design for targeted therapeutics. Nature (2017) 550, 74-79.

Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. J Med Chem (2017) 60, 658-667.

Cyclotide structure and function: role of membrane binding and permeation. Biochemistry (2017) 56, 669-682.

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNav1.7. Biochim Biophys Acta Biomembr (2017) 1859, 835-844

Orientation and location of the cyclotide kalata B1 in phospholipid bilayers revealed by solid-state NMR. Biophys J (2017) 112, 630-642

α-conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut (2017) 66, 1083-1094

Cyclotides as drug design scaffolds. Curr Opin Chem Biol (2017) 38, 8-16.

Kalata B1 and kalata B2 have a surfactant-like activity in phosphatidyl ethanolomine (PE) containing lipid membranes. Langmuir (2017) 33, 6630- 6637.

α-Conotoxin [S9A]TxID potently discriminates α3β4 and α6/α3β4 nicotinic acetylcholine receptors. J Med Chem (2017) 60, 5826-5833

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET. Proc Natl Acad Sci U S A (2017) 114, E1857-1865

Redesigned spider toxin with improved antimicrobial and anticancer and properties. ACS Chem Biol (2017) 12, 2324-2334

Hydrogen-adduction to Open-Shell Graphene Fragments: Spectroscopy, Thermochemistry and Astrochemistry. Chem. Sci. (2017) 8, 1186-1194.

Synthesis of Norfijimycin A with activity against Mycobacterium tuberculosis. Aust. J. Chem. (2017) 70, 229-232

One-Pot Ligation–Oxidative Deselenization at Selenocysteine and Selenocystine. Chem. Eur. J. (2017) 23, 946-952.

Synthesis of rhamnosylated arginine glycopeptides and determination of the glycosidic linkage in bacterial elongation factor P. Chem. Sci. (2017) 8, 2296-2302

Sansanmycin Natural Product Analogues as Potent and Selective Anti-Mycobacterials that Inhibit Lipid I Biosynthesis. Nature Commun. (2017) 8, 14414

Synthesis of a GlcNAcylated arginine building block for the solid phase synthesis of death domain glycopeptide fragments. Bioorg. Med. Chem. (2017) 25, 2895-2900.

New Tuberculosis Drug Leads from Naturally Occuring Compounds. Int. J. Infect. Dis. (2017) 56, 212-220.

The cell surface mucin MUC1 limits the severity of influenza A virus infection. Mucosal Immunol. (2017) 10, 1581-1593

Solid-Phase Synthesis of Peptide Selenoesters via a Side-Chain Anchoring Strategy. Chem. Commun. (2017) 53, 5424-5427

Sulfation of Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES. Angew. Chem. Int. Ed. (2017) 56, 8490-8494.

Accelerated Protein Synthesis via One-Pot Ligation–Deselenization Chemistry. Chem. (2017) 2, 703–715

Ticks from diverse genera encode chemokine-inhibitory evasin proteins. J. Biol. Chem. (2017) 292, 15670-15680.

CCR7 sulfotyrosine enhances CCL21 binding, Int. J. Mol. Sci. (2017) 18, 1857

Semisynthetic Prion Protein (PrP) variants carrying glycan mimics at position 181 and 197 do not form fibrils. Chem. Sci. (2017) 8, 6626-6632

Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors. Nature Chem. (2017) 9, 909-917.

Multiplexed temporal quantification of the exercise-regulated plasma peptidome. Mol. Cell. Prot. (2017) 16, 2055-2068.

Diverse peptide hormones affecting root growth identified in the Medicago truncatula secreted peptidome. Mol. Cell. Prot. (2017) 17, 160-174.

Total Synthesis of Glycinocins A-C. J. Org. Chem. (2017) 82, 12778-12785.

Structural requirements of flavonoids to induce heme oxygenase-1 expression. Free Radical Biol. Med. (2017) 113, 165-175.

Total Synthesis of Skyllamycins A-C. Chem. Eur. J. (2017) 23, 15046-15049.

The Structural Basis of Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech. J. Immunol. (2017) 199, 3883-3891

Arabinosylation Modulates the Growth-Regulating Activity of the Peptide Hormone CLE40a from Soybean. Cell Chem. Biol. (2017) 24, 1347-1355

Variation in Major Histocompatibility Complex diversity in invasive cane toad populations. Wildlife Research, (2018) 44, 565-572.

Long-read genome sequence assembly provides insight into ongoing retroviral invasion of the koala germline. Scientific Reports, (2017) 7

Marsupial and monotreme cathelicidins display antimicrobial activity, including against methicillin-resistant Staphylococcus aureus. Microbiology (2017) 163, 1457-1465.

Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association. Scientific Reports, (2017) 7.

Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils. Scientific Reports, (2017) 7.

No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding. Scientific Reports, (2017) 7.

Increasing generations in captivity is associated with increased vulnerability of Tasmanian devils to vehicle strike following release to the wild. Scientific Reports, (2017) 7, 2161.

Immune-endocrine interactions in marsupials and monotremes. General and Comparative Endocrinology, (2017) 244, 178-185.

Significant decline in anticancer immune capacity during puberty in the Tasmanian devil. Scientific Reports, (2017) 7

Characterisation of MHC class I genes in the koala. Immunogenetics, pp.1-9 (2017) 70, 125-133.

“Devil tools & tech”: a synergy of conservation research and management practice. Conservation Letters (2017) 10, 133-138

Antimicrobial protection of marsupial pouch young. Frontiers in Microbiology, (2017). 8, 354.

Characterization of the antimicrobial peptide family defensins in the Tasmanian devil (Sarcophilus harrisii), koala (Phascolarctos cinereus), and tammar wallaby (Macropus eugenii). Immunogenetics, (2017) 69 133-143

pH-Responsive, amphiphilic core-shell supramolecular polymer brushes from cyclic peptide – polymer conjugates. ACS Macro Lett (2017) 6, 1347–1351.

Fluorescent Sensing Arrays for Cations and Anions. Analyst, (2017) 142, 3549 – 3563.

Quantum Chemical Prediction of Equilibrium Acidities of Ureas, Deltamides, Squaramides and Croconamides, J Org Chem (2017) 82, 10732−10736.

Pyrophosphate recognition and sensing in water using bis[zinc(II)dipicolylamino]-functionalised peptides. Acc Chem Res (2017) 50, 2254-2263.

Pressure controlled polymerisation/depolymerisation of a copper(II)-containing coordination polymer. Chem Eur J (2017) 23, 12480 – 12483.

Synthesis of side-chain modified peptides using iterative solid phase ‘click’ methodology. Aust J Chem (2017) 70, 201-207.

Carborane-Containing Fluorophore as a Stain of Cellular Lipid Droplets. Chemistry-an Asian Journal. (2017) 12, 1704-8.

Versatility of Terpyridine-Functionalised Aryl Tetrazoles: Photophysical Properties, Ratiometric Sensing of Zinc Cations and Sensitisation of Lanthanide Luminescence. European Journal of Inorganic Chemistry. (2017) 44, 5260-70.

A cobalt(II) complex with unique paraSHIFT responses to anions. Chemical Communications. (2017) 53, 3571-4.

Hypoxia-Responsive Cobalt Complexes in Tumor Spheroids: Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Magnetic Resonance Imaging Studies. Inorganic Chemistry. (2017) 56 9860-8.

Imaging metals in biology: pictures of metals in health and disease. Metallomics. (2017) 9, 343-5.

Insecticidal activities of histone deactylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina. Int J Parasitol: Drugs and Drug Resistance (2017) 7, 51-60.

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth. Int J Parasitol: Drugs and Drug Resistance (2017) 7, 42-50.

Alpha helix nucleation by a simple cyclic tetrapeptide. Aust J Chem (2017) 70, 213–219.

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51. Bioorg Med Chem Lett (2017) 27, 3096-3100.

Histone deacetylases (HDAC) in physiological and pathological bone remodeling. Bone (2017) 95, 162–174.

Tolyporphin macrocycles from the cyanobacterium Tolypothrix nodosa selectively bind copper and silver and reverse multidrug resistance. Inorg Chem (2017) 56, 5577–5585.

The ribosomal protein S19 suppresses antitumor immune responses via the complement C5a receptor 1. J Immunol (2017) 198, 2989-2999.

Biased signaling by agonists of protease activated receptor 2. ACS Chem Biol (2017) 12, 1217–1226.

Mucosal-associated invariant T cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co- stimulatory signals. Mucosal Immunology (2017) 10, 58-68.

Total synthesis of the Mycobacterium tuberculosis dideoxymycobactin-838 and stereoisomers: Diverse CD1a-restricted T cells display a common hierarchy of lipopeptide recognition. Chem Eur J (2017) 23, 1694-1701.

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling. Pharmacol Res (2017) 117, 328-342.

An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice. J Pharmacol Exp Ther (2017) 360, 140-51.

Helix-constraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta arrestin 2 signalling. Eur J Med Chem (2017) 127, 703-714.

Electrophilic helical peptides that bind covalently, irreversibly and selectively in a protein-protein interaction site. ACS Med Chem Lett (2017) 8, 22−26.

Downsizing protooncogene cFos to short helix-constrained peptides that bind Jun. ACS Chem Biol (2017) 12, 2051-2061.

Protease activated receptor 2 controls myelin development, resiliency and repair. Glia (2017) 65, 2070-2086.

Drugs and drug-like molecules can modulate the function of mucosal- associated invariant T cells. Nature Immunol (2017) 18, 402-411.

Stabilising short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells. Nature Communications (2017) 8, 14599.

Melt with this kiss: paralysing and liquefying venom of the assassin bug Pristhesancus plagipennis (Hemiptera: Reduviidae). Molecular & Cellular Proteomics (2017) 16, 522–566.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Scientific Reports (2017) 7, 40883

Revisiting venom of the sea anemone Stichodactyla haddoni: omics techniques reveal the complete toxin arsenal of a well-studied sea anemone genus. Journal of Proteomics (2017) 66, 83–92.

Venom peptides as therapeutics: advances, challenges and the future of venom-peptide discovery. Expert Review of Proteomics (2017) 14, 931–939.

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology (2017) 174, 2528–2544.

Improved efficacy of an arthropod toxin expressing fungus against insecticide-resistant malaria-vector mosquitoes. Scientific Reports (2017) 7, 3433.

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant. PloS One (2017) 12, e0173551.

Structural and functional characterization of chimeric cyclotides from the Mobius and trypsin inhibitor subfamilies, Biopolymers-Pept Sci, (2017) 108, e22927.

Gating modifier toxins interactions with ion channels and lipid bilayers: Is the trimolecular complex real? Neuropharmacology, (2017) 127, 32-45.

Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake Biopolymers-Pept Sci, (2017) 108, e23025

Lengths of the C-terminus and interconnecting loops impact stability of spider-derived gating modifier toxins, Toxins, (2017) 12, e248

Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags. Prog. NMR Spectr. (2017) 98-99, 20-49.

Protein structure determination by assembling super-secondary structure motifs using pseudocontact shifts. Structure (2017) 25, 559-568.

Structure restraints from heteronuclear pseudocontact shifts generated by lanthanide tags at two different sites. J. Biomol. NMR (2017) 68, 19- 32.

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease. Antiviral Res. (2017) 142, 141- 168.

New lanthanide tag for the generation of pseudocontact shifts in DNA by site-specific ligation to a phosphorothioate group. Bioconjugate Chem. (2017) 28, 1741-1748.

Double-arm lanthanide tags deliver narrow Gd3+–Gd3+ distance distributions in double electron- electron resonance (DEER) measurements. Chem. Eur. J. (2017) 23, 11694-11702.

Chemical tagging with t-butyl and trimethylsilyl groups for measuring intermolecular NOEs in a large protein-ligand complex. Chem. Eur. J. (2017) 23, 13033-13036.

Selective distance measurements using triple spin labeling with Gd3+, Mn2+ and a nitroxide. J. Phys. Chem. Lett. (2017) 8, 5277-5282.

Site-selective tagging of proteins by pnictogen-mediated self-assembly. Chem. Commun. (2017) 53, 10894-10897.

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity. J. Am. Chem. Soc. (2017) 139, 3209- 3226.

Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms. Angew. Chem. Int. Ed. (2017) 56, 260-265.

Transition Metal-Promoted Arylation: An Emerging Strategy for Protein Bioconjugation. Aust. J. Chem. (2017) 69, 1360-1364.

Decarboxylative Alkenylation. Nature (2017) 545, 213-218.

Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products. J. Am. Chem. Soc. (2017) 139, 5233-5241.

The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria. ISME J. (2017) 11, 125-137.

The Evolution of New Catalytic Mechanisms for Xenobiotic Hydrolysis in Bacterial Metalloenzymes. Aust. J. Chem. (2017) 69, 1383-1395.

Constrained evolution of a bispecific enzyme: lessons for biocatalyst design. Org. Biol. Chem. (2017) 15, 937-946.

Structural reconstruction of protein ancestry. Proc. Natl. Acad. Sci. USA. (2017) 114, 3897.

Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila. Sci. Rep. (2017) 7, 46188.

Mycobacterial F420H2-dependent reductases promiscuously reduce diverse compounds through a common mechanism. Frontiers Microbiol., (2017) 8, 1000.

The Synthesis of Certain Derivatives and Analogues of (−)-and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase. J. Org. Chem. (2017) 82, 7869-7886.

Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase. Eur. J. Org. Chem. (2017) 4044-4053.

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein. PLoS Pathogens. (2017) 13, e1006469.

Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases. Frontiers Microbiol., (2017) 8, 1902.

Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge? Biochemistry. (2017) 56, 5512-5525.

SNaPe: a versatile method to generate multiplexed protein fusions using synthetic linker peptides for in vitro applications, J. Pep. Sci. (2017) 23, 16-27.

Diversity of nature’s assembly lines – recent discoveries in non-ribosomal peptide synthesis, Mol. BioSyst. (2017) 13, 9-22.

Chlorinated Glycopeptide Antibiotic Peptide Precursors Improve Cytochrome P450-Catalyzed Cyclization Cascade Efficiency, Biochemistry (2017) 56, 1239-1247.

P450 monooxygenase ComJ catalyses side chain phenolic cross-coupling during complestatin biosynthesis, RSC Adv. (2017) 7, 35376-35384.

Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis, Chem. Sci. (2017) 8, 5992-6004.

Uncovering protein-protein interactions through a team-based undergraduate biochemistry course. PLoS Biol. (2017) 15, e2003145

Selective spider toxins reveal a role for the NaV1.1 channel in mechanical pain. Nature (2016) 534, 494–499

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers-Pept Sci, (2016) 106, 853-863

The coming of age of de novo protein design. Nature (2016) 537, 320-327.

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers: Pept Sci (2016) 106, 89-100

Inhibition of tau aggregation using a naturally- occurring cyclic peptide scaffold. Eur J Med Chem (2016) 109, 342-349.

Gene coevolution and regulation lock cyclic plant defence peptides to their targets. New Phytol (2016) 210, 717-730.

Structure-activity studies of cysteine-rich α-conotoxins that inhibit high voltage-activated calcium channels via GABAB receptor activation reveal a minimal functional motif. Angew Chem (2016) 55, 4692-4696.

Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. J Am Chem Soc (2016) 138, 5706-5713.

Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic sodium channel NaV1.8. J Biol Chem (2016) 291, 11829-11842.

Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency, α-helicity and reveal interactions vital for cAMP signalling in vitro. J Biol Chem (2016) 291, 15778-15787.

Discovery, structure, function and applications of cyclotides: circular proteins from plants. J Exp Bot (2016) 67, 4801-4812

Substrate guided design of potent FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. J Med Chem (2016) 59, 7287-7292

Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel Nav1.7. J Biol Chem (2016) 291, 17049- 17065

Constrained cyclic peptides as immunomodulatory inhibitors of the CD2:CD58 protein-protein interaction. ACS Chem Biol (2016) 11, 2366-74.

Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant. Antimicrob Agents and Chemother (2016) 60, 6302-6012.

Dual targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep (2016) 6, 35347

Accurate de novo design of hyperstable constrained peptides. Nature (2016) 538, 329-335

Discovery and optimization of peptide macrocycles. Expert Opin Drug Discov (2016) 11, 1151-1163.

Cyclic peptide oral bioavailability: Lessons from the past. Biopolymers: Pept Sci (2016) 106, 901-909.

Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: An IUPAC task group interim report. Biopolymers: Pept Sci (2016) 106, 917-924

Characterization of a bioactive acyclotide from Palicourea rigida. J Nat Prod (2016) 79, 2767-2773.

Isolation and characterization of cyclotides from Brazilian Psychotria: significance in plant defense and co-occurrence with antioxidant alkaloids. J Nat Prod (2016) 79, 3006-3013.

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science, (2016) 351, 186-190.

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells. J. Cell Sci. (2016) 129, 1340-1354

Total Synthesis of Native 5,7-Diacetylpseudaminic Acid from N-Acetylneuraminic Acid. J. Org. Chem. (2016) 81, 2607-2611.

Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding. Org. Biomol. Chem. (2016) 14, 5652-5658.

Total Synthesis of Teixobactin. Org. Lett. (2016) 18, 2788-2791

Single Addition of an Allyl Amine Monomer Enables Access to End-Functionalized RAFT Polymers for Native Chemical Ligation. Chem. Commun. (2016) 52, 12952-12955.

4-nitrophenylchloroformate. eEROS: Encyclopedia of reagents for organic synthesis. (2017)

Evolution and comparative analysis of the bat MHC-I region. Scientific Reports, (2016) 6.

Immunoglobulin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii). Scientific Reports, (2016) 6.

Transmissible cancers in an evolutionary context. BioEssays, (2016) 38, S14-S23

Cathelicidins in the Tasmanian devil (Sarcophilus harrisii). Scientific Reports, (2016) 6.

Comparison of genotypes of Toxoplasma gondii in domestic cats from Australia with latent infection or clinical toxoplasmosis. Veterinary parasitology, (2016) 228, 13-16

Allelic expression of mammalian imprinted genes in a matrotrophic lizard, Pseudemoia entrecasteauxii. Development Genes and Evolution, (2016) 226, 79-85.

Characterisation of the immune compounds in koala milk using a combined transcriptomic and proteomic approach. Scientific Reports (2016) 6, 35011

Reptile pregnancy is underpinned by complex changes in uterine gene expression: a comparative analysis of the uterine transcriptome in viviparous and oviparous lizards. Genome Biology and Evolution (2016) 8, 3226-3239

Molecular characterisation of MHC class II in the Australian invasive cane toad reveals multiple splice variants. Immunogenetics. (2016) 68, 449-460

The identification of immune genes in the milk transcriptome of the Tasmanian devil (Sarcophilus harrisii). PeerJ. (2016)

Study of (cyclic peptide)-polymer conjugate assemblies by small angle neutron scattering.

Tunable length of cyclic peptide-polymer conjugate self-assemblies in water. ACS Macro Lett (2016) 5, 1119-1123.

The Impact of Structural Variation in Simple Lanthanide Binding Peptides. RSC Advances (2016) 6, 75336-75346.

Are two better than one? Comparing Indicator Displacement Assays with Covalent Indicator Attachment in Anion Recognition. Chem Commun (2016) 52, 8463-8466.

Macrocyclic Squaramides: Anion Receptors with High Sulfate Binding Affinity and Selectivity in Aqueous Media Chem Sci (2016) 7, 4563 - 4572.

Triazole containing zinc(II)dipicolylamine-functionalised peptides as highly selective pyrophosphate sensors in physiological media, Supramol. Chem., (2016) 28, 192-200.

Cyclic peptide-polymer conjugates: grafting to vs grafting from. J Polym Sci A; Polym Chem (2016) 54, 1003-1011.

Synthesis and Characterization of Metal Complexes with Schiff Base Ligands. Journal of Chemical Education. (2016) 93, 351-4.

A library- screening approach for developing a fluorescence sensing array for the detection of metal ions. Analyst. (2016) 141, 4608-13.

A ratiometric fluorescent sensor for the mitochondrial copper pool. Metallomics. (2016) 8, 915-9.

Reversible magnetogenic cobalt complexes. RSC Advances. (2016) 6, 30021-7

Harnessing the Potential of Small Molecule Intracellular Fluorescent Sensors. ACS Sensors. (2016) 1, 328-33.

Copper regulates cyclic-AMP-dependent lipolysis. Nature Chemical Biology. (2016) 12, 586- 592.

Selective and Reversible Approaches Toward Imaging Redox Signaling Using Small-Molecule Probes. Antioxidants & Redox Signaling. (2016) 24, 713-30.

Reversible Fluorescent Probes for Biological Redox States. Angewandte Chemie-International Edition. (2016) 55, 1602-13.

Studies of Hematopoietic Cell Differentiation with a Ratiometric and Reversible Sensor of Mitochondrial Reactive Oxygen Species. Antioxidants & Redox Signaling. (2016) 24, 667-79.

On the outside looking in: redefining the role of analytical chemistry in the biosciences. Chemical Communications. (2016) 52, 8918-34.

Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases Clin Transl Immunology (2016) 5, e62.

Stapling peptides using cysteine crosslinking. Biopolymers (2016) 106, 843-852.

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Science Reports (2016) 6, 24575.

PAR2 modulators derived from GB88. ACS Med Chem Lett (2016) 7, 1179–1184.

Protease activated receptor 2 (PAR2) modulators: a patent review (2010- 2015). Expert Opinion on Therapeutic Patents (2016) 26, 471-483.

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Bioorg Med Chem Lett (2016) 25, 5604-5608.

Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages. Antimicrobial Agents and Chemotherapy (2016) 60, 1521-1529.

Downsizing BAD BH3 peptide to small constrained helices with improved ligand efficiency. Org Biomol Chem (2016) 14, 10939-45.

Human mucosal-associated invariant T cells contribute to anti-viral influenza immunity via IL-18 dependent activation. Proc Natl Acad Sci USA (2016) 113, 10133-8.

Differential anti-inflammatory activity of low versus high dose HDAC inhibitors in human macrophages and collagen induced arthritis in rats. J Pharm Exp Ther (2016) 356, 387-396.

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease activated receptor 2. Br J Pharmacol (2016) 173, 2752-2765.

Potent small agonists of protease activated receptor 2 ACS Med Chem Lett (2016) 7, 105–110.

Membrane-anchored serine protease matriptase is a trigger of pulmonary fibrogenesis. Am J Respir Critical Care Medicine (2016) 193, 847-860.

The intracellular pathway for MR1 presentation of vitamin B- related antigens. Nature Immunology (2016) 17, 531-537.

A three-stage intrathymic development for mucosal-associated invariant T cell lineage. Nature Immunology (2016) 17, 1300-1311.

Helix nucleation by the smallest known alpha helix in water. Angew Chem Int Edit (2016) 55, 8275-9.

Diversity of T cells restricted by the MHC class I-related molecule MR1 facilitates differential antigen recognition. Immunity (2016) 44, 32-45.

Molecular basis of the interaction between gating modifer toxins and the voltage sensor of voltage-gated ion channels. Scientific Reports (2016) 6, 34333.

Toxin structures as evolutionary tools: using conserved 3D folds to study the evolutionary trajectory of rapidly evolving peptides. BioEssays (2016) 38, 539–548.

Venoms of heteropteran insects: a treasure trove of diverse pharmacological toolkits. Toxins (2016) 4, 43.

Centipede venoms as a source of drug leads. Expert Opinion on Drug Discovery (2016) 11, 1139–1149.

Membrane-binding properties of gating-modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. Biochimica et Biophysica Acta – Biomembranes (2016) 1858, 872–882.

Using the MCoTI-II cyclotide scaffold to design stable cyclic peptides antagonist of SET, a protein overexpressed in human cancer, Biochemistry, (2016) 55, 396-405

Luminescent alkyne-bearing terbium(III) complexes and their application to bioorthogonal protein and peptide labeling. Inorg. Chem. (2016) 55, 1674-1682

Pulse EPR-enabled interpretation of scarce pseudocontact shifts induced by lanthanide binding tags. J. Biomol. NMR (2016) 64, 39-51

Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy. Phys. Chem. Chem. Phys. (2016) 18, 5850-5859.

Pseudocontact shift-driven iterative resampling for 3D structure determinations of large proteins. J. Mol. Biol. (2016) 428, 522-532.

Sensitive NMR approach for determining the binding mode of tightly binding ligand molecules to protein targets. J. Am. Chem. Soc. (2016) 138, 4539-4546

Overcoming artificial broadening in Gd3+-Gd3+ distance distributions arising from dipolar pseudo-secular terms in DEER experiments. Phys. Chem. Chem. Phys. (2016) 18, 12847-12859.

RIDME distance measurements using Gd(III) tags with a narrow central transition. Phys. Chem. Chem. Phys. (2016) 18, 19037-19049

3D structure determination of an unstable transient enzyme intermediate by paramagnetic NMR spectroscopy. Angew. Chem. Int. Ed. (2016) 55, 13744-13748.

Using paramagnetism to slow down nuclear relaxation in protein NMR. J. Phys. Chem. Lett. (2016) 7, 4815-4818.

Strain-Release Amination. Science, (2016) 351, 241-246.

A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents. Science, (2016) 352, 801-805.

Structural and thermodynamic insights into the evolution of binding specificity from ancestral solute-binding proteins, Cell Chem. Biol. (2016) 23, 236-245.

Conformational disorganization within the active site of a recently evolved organophosphate hydrolase limits its catalytic efficiency. Biochemistry. (2016) 55, 1408-1417.

Protonation state of F420H2 in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis. Mol. BioSyst. (2016) 12, 1110-1113.

Physiology, biochemistry, and applications of F420-and Fo-dependent redox reactions. Micro. Mol. Biol. Rev. (2016) 80, 451-493.

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability. J. Mol. Biol. (2016) 428, 2359-2371.

Phosphorescent oxygen- sensing and singlet oxygen production by a biosynthetic silk. RSC Advances. (2016) 6, 39530-39533.

Mapping the accessible conformational landscape of an insect carboxylesterase using kinetic crystallography and conformational ensemble analysis. Structure. (2016) 24, 977-987.

The role of rotein dynamics in the evolution of new enzyme function. Nat. Chem. Biol. (2016) 12, 944-950.

Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase. Proc. Natl. Acad. Sci. USA. (2016) 113, E4567–E4576.

Rv2074 is a novel F420H2-dependent biliverdin reductase in Mycobacterium tuberculosis. Prot. Sci. (2016) 25, 1692-1709.

Classification and substrate head-group specificity of membrane fatty acid desaturases. J. Comp. Struct. Biotech. (2016) 14, 341-349.

Hydrophobic Shielding Drives Catalysis of Hydride Transfer in F420H2-Dependent Enzymes. Biochemistry. (2016) 55, 6908-6918.

Active site desolvation and thermostability tradeoffs in the evolution of catalytically diverse triazine hydrolases. Biochemistry. (2016) 55, 6304-6313.

Probing the Mechanisms for the Selectivity and Promiscuity of Methyl Parathion Hydrolase. Phil. Trans. Royal. Soc. A. (2016) 374, 0150.

Conformational tinkering drives evolution of a promiscuous activity through indirect mutational effects. Biochemistry. (2016) 55, 4583-4593.

The redox cofactor F420 protects mycobacteria from diverse antimicrobial compounds and mediates a reductive detoxification system. App. Env. Micro. (2016) 82, 6810-6818.

Rangefinder: A Semisynthetic FRET Sensor Design Algorithm. ACS Sensors. (2016) 1, 1286-1290.

Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis, MedChemComm (2016) 7, 132-140.

Probing the selectivity of beta-hydroxylation reactions in non-ribosomal peptide synthesis using analytical ultracentrifugation, Anal. Biochem. (2016) 495, 42-51.

Online pyrophosphate assay for analyzing adenylation domains of non- ribosomal peptide synthetases, ChemBioChem (2016) 17, 576-584.

Structure of OxyA tei: completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade, FEBS Lett. (2016) 590, 571-581.

Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis, J. Am. Chem. Soc. (2016) 138, 6746-6753.

Understanding the crucial interactions between Cytochrome P450s and non-ribosomal peptide synthetases during glycopeptide antibiotic biosynthesis, Curr. Opin. Struct. Biol. (2016) 41, 46-53.

Have substrate, will travel: new structural data reveals the motion of carrier proteins in non-ribosomal peptide synthesis, Angew. Chemie Int. Ed. (2016) 55, 9834-9840.

More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH, Mol. BioSyst. (2016) 12, 2992-3004.

F-O-G Ring Formation in Glycopeptide Antibiotic Biosynthesis is Catalysed by OxyE, Sci. Rep. (2016) 6, 35584.

Catalytic promiscuity of glycopeptide N- methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates, Chem. Commun. (2016) 52, 13679-13682.

Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934, Beilstein J. Org. Chem. (2016) 12, 2849-2864.

Unique post- translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chem. Sci. (2016) 7, 482-488.

LC-MS guided isolation of penicilfuranone A: a unique antifibrotic furancarboxylic acid from the plant endophytic fungus Penicillium sp. sh18. J. Nat Prod. (2016) 79, 149-155.

A flavin-dependent decarboxylase-dehydrogenase-monooxygenase assembles the warhead of α, β- epoxyketone proteasome inhibitors. J. Am. Chem. Soc. (2016) 138, 432-435.

The structure, chemical synthesis and biosynthesis of prodiginine natural products. Chem. Rev. (2016) 115, 7818-7853.

Discovery of an unusual biaryl polyketide by activation of a silent Streptomyces venezuelae biosynthetic gene cluster. ChemBioChem, (2016) 17, 2189-2198.

Mechanistic insights into class B radical-S- adenosylmethionine methylases: ubiquitous tailoring enzyzmes in natural product biosynthesis. Curr. Opin. Chem. Biol. (2016) 35, 73-79.

A crotonyl-CoA reductase/carboxylase-independent pathway for unusual alkylmalonyl-CoA polyketide synthase extender unit biosynthesis. Nat. Commun. (2016) 7, 13609.

The evolution of Momordica cyclic peptides. Mol Biol Evol (2015) 32, 392-405

In vivo efficacy of anuran trypsin inhibitory peptides against Staphylococcal skin infection and the impact of peptide cyclization. Antimicrob Agents Chemother (2015) 59, 2113-2121

Solution structure, aggregation behaviour and flexibility of human relaxin-2. ACS Chem Biol (2015) 10, 891- 900

Optimization of the cyclotide framework to improve cell penetration properties. Front Pharmacol (2015) 6 17

Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding. J Biol Chem (2015) 290 9855-9862

Peptide macrocyclization by a bifunctional endoprotease. Chem Biol (2015) 22, 571-582

Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability. Eur J Med Chem (2015) 97, 202-213

Bioinformatics-aided venomics. Toxins (2015) 7, 2159-2187

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochem J (2015) 469, 243-253

Cloning, synthesis and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proc Natl Acad Sci U S A (2015) 112, E4026-E4035.

Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Sci Rep (2015) 5, 12974

Identification, characterization and the three-dimensional structure of the novel circular bacteriocin, enterocin NKR-5-3B, from Enterococcus faecium. Biochemistry (2015) 54, 4863-4876

Less is more: design of a highly stable disulfide-deleted mutant of analgesic cyclic α-conotoxin Vc1.1. Sci Rep (2015) 5, 13264

The prototypic cyclotide kalata B1 has a unique mechanism of entering cells. Chem Biol (2015) 22, 1087-1097

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. Eur J Med Chem (2015) 103, 175-184

Lysine-rich cyclotides: a new subclass of circular knotted proteins. ACS Chem Biol (2015) 10, 2491-2500

Improving the selectivity of engineered protease inhibitors: Optimizing the P2 prime residue using a versatile cyclic peptide library. J Med Chem (2015) 58, 8257- 8268.

Distribution of circular proteins in plants: Large scale mapping of cyclotides in the Violaceae. Front Plant Sci (2015) 6, 855

Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins. Biopolymers: Pept Sci (2015) 104, 682-692

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase. Nat Commun (2015) 6, 10199

Effects of cyclization on peptide backbone dynamics. J Phys Chem B (2015) 119, 15821-15830

Two Blast-independent tools, CyPerl and CyExcel, for harvesting hundreds of novel cyclotides and analogues from plant genomes and protein databases. Planta (2015) 241, 929-940

Synthetic Amino Acids for Applications in Peptide Ligation-Desulfurization Chemistry. Aust. J. Chem. (2015) 68, 521-537

Phosphatemodulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Org. Biomol. Chem. (2015) 13, 2162-2169

Synthesis and Evaluation of Phenoxymethylbenzamide Analogues as Anti-Trypanosomal Agents. Med. Chem. Commun. (2015) 6, 403-406

A defined α-helix in the bifunctional O-glycosylated natriuretic peptide TcNPa from the venom of Tropidechis carinatus. Angew. Chem. Int. Ed. (2015) 54 4828-31

Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation–Desulfurization Chemistry. Org. Lett. (2015) 17 2070-2073

Homogeneous Sulfopeptides and Sulfoproteins: Synthetic Approaches and Applications to Characterize the Effects of Tyrosine Sulfation on Biochemical Function. Acc. Chem. Res. (2015) 48, 2251-2261

Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine. Angew. Chem. Int. Ed. (2015) 54, 12716-12721

Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines. Front. Chem. (2015) 3, 60

Thiazolidine-Protected β-Thiol Asparagine: Applications in One-Pot Ligation-Desulfurization Chemistry. Org. Lett. (2015) 17, 4902-4905.

Rapid Additive- Free Selenocystine–Selenoester Peptide Ligation. J. Am. Chem. Soc. (2015) 137, 14011-14014

Development of a SNP-based assay for measuring genetic diversity in the Tasmanian devil insurance population. BMC Genomics (2015) 16 791

Genomics insights into a contagious cancer in Tasmanian devils. Trends in Genetics (2015) 31, 528-535

Identification and analysis of divergent immune gene families within the Tasmanian devil genome. BMC Genomics (2015) 16, 1017.

The Tasmanian devil microbiome- implications for conservation and management. Microbiome (2015) 3, 76

Lack of genetic diversity across diverse immune genes in an endangered mammal, the Tasmanian devil (Sarcophilus harrisii). Molecular Ecology (2015) 24, 3860-3872

SNP marker discovery in koala TLR genes. PLoS One (2015) 10 e0121068

Impacts of early viability selection on management of inbreeding and genetic diversity in conservation. Molecular Ecology (2015) 24, 1645-1653

Diversity in the Toll-like receptor genes of the Tasmanian devil (Sarcophilus harrisii). Immunogenetics (2015) 67, 195-201

Selection on MHC class II supertypes in the New Zealand endemic Hochstetter’s frog. BMC Evolutionary Biology (2015) 15, 63

Detection of Aspergillus-specific antibodies by agar gel double immunodiffusion and IgG ELISA in feline upper respiratory tract aspergillosis. The Veterinary Journal, (2015) 203, 285-289

Evolution of the avian β- defensin and cathelicidin genes. BMC evolutionary biology, (2015) 15, 188.

The origin, dynamics, and molecular evolution of transmissible cancers. Advances in Genomics and Genetics, (2015) 5, 317-326

Identification, characterisation and expression analysis of natural killer receptor genes in Chlamydia pecorum infected koalas (Phascolarctos cinereus). BMC genomics, (2015) 16, 796.

Characterization of antibody V segment diversity in the Tasmanian devil (Sarcophilus harrisii). Veterinary immunology and immunopathology, (2015) 167, 156-165

Interrogating Novel Zinc(II)dipicolylamine Anion Sensors via Mass Spectrometry and Ion Mobility Mass Spectrometry, Int J Mass Spectrom (2015) 391, 62-70.

Selective sensing of pyrophosphate in physiological media using zinc(II)dipicolylamino-functionalised peptides. Org Biomol Chem (2015) 13, 7822-7829.

pH switchable anion transport by an oxothiosquaramide Chem Commum (2015) 51, 10107-10110.

Total synthesis and reassignment of the structures of the antimicrobial lipodepsipeptides circulocins γ and δ. J Org Chem (2015) 80, 4491-4500.

Anion Recognition by Cyclic Peptides. Chem Commun (2015) 51, 4951-4968.

Effect of the amino acid composition of cyclic peptides on their self-assembly in lipid bilayers. Org Biomol Chem (2015) 13, 2464 - 2473.

Luminescent probes for the bioimaging of small anionic species in vitro and in vivo. Chem Soc Rev (2015) 44, 4547-4595.

Fluorescent and Colorimetric Chemosensors for Pyrophosphate. Chem Soc Rev (2015) 44, 1749-1762.

Synthesis of Dichotomin A: Use of a Penicillamine Derived Pseudoproline to Furnish Native Valine Residues, Aust J Chem (2015) 68, 627-634.

Amino Acid Based Squaramides for Anion Recognition. Supramol Chem (2015) 27, 321-328.

Selective Solvent Extraction of Silver(I) by Tris-pyridyl Tripodal Ligands and X-ray Structure of a Silver(I) Coordination Polymer Incorporating One Such Ligand. Aust J. Chem. (2015) 68, 549-554.

What has fluorescent sensing told us about copper and brain malfunction? Metallomics. (2015) 7, 56-65.

Fluorescent sensing of monofunctional platinum species. Chemical Communications. (2015) 51, b6312-4.

Imaging mitochondrial hydrogen peroxide in living cells. Methods in molecular biology. (2015) 1264, 231-43.

A FRET-based ratiometric redox probe for detecting oxidative stress by confocal microscopy, FLIM and flow cytometry. Chemical Communications. (2015) 51, 10510-3.

Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells. Organic & Biomolecular Chemistry. (2015) 13, 6686-9.

Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution. Chemical Society Reviews. (2015) 44, 5941-58.

Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception, in Nociceptin Opioid, Vitamins and Hormones (2015) 97, 1–55.

Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. Int J Parasitol Drugs Drug Resist (2015) 5, 201-208.

Towards peptide-based inhibitors as therapies for Parkinson’s disease. Future Med Chem (2015) 7, 2103-2105.

Potent C3a receptor agonists derived from oxazole amino acids. Structure-activity relationships. Bioorg Med Chem Lett (2015) 25, 5604-8.

Inhibiting histone deacetylase 1 (HDAC 1) suppresses both inflammation and bone loss in arthritis. Rheumatology (2015) 54, 1713-1723.

Repurposing registered drugs as antagonists for protease-activated receptor 2. J Chem Inf Model (2015) 55, 2079-84.

Three homology models of PAR2 derived from different templates: application to antagonist discovery. J Chem Inf Model (2015) 55, 1181-1191.

Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets. J Mol Graphics Modelling (2015) 57, 76-88.

Flexibility versus rigidity for orally bioavailable cyclic hexapeptides. ChemBioChem (2015) 16, 2289-2293.

Identification of phenotypically and functionally heterogeneous mouse mucosal associated invariant T cells using MR1 tetramers. J Exp Med (2015) 212, 1095-1108.

Recognition of antigens derived from vitamin B precursors by mucosal associated invariant T cells. J Biol Chem (2015) 290, 30204-11.

Functional heterogeneity and anti-mycobacterial effects of mouse mucosal associated invariant T (MAIT) cells specific for riboflavin metabolites. J Immunol (2015) 195, 587-601.

Facile synthesis of mono- and bis-methylated Fmoc- Dap, -Dab and -Orn amino acids. Chem Commun (2015) 51, 4496-4498.

Nutrient and immune sensing are obligate pathways in metabolism, immunity and disease. FASEB J (2015) 29, 3612-3625.

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system. ACS Chem Biol (2015) 10, 957–964.

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence. J Med Chem (2015) 58, 577-87.

Short hydrophobic peptides with cyclic constraints are potent GLP-1R agonists, J Med Chem (2015) 58, 4080-4085.

Mutations in the voltage-gated potassium channel KCNH1 cause Temple–Baraitser syndrome and non-syndromic epilepsy. Nature Genetics (2015) 47, 73–77

Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint. Proceedings of the National Academy of Sciences USA (2015) 112, 4026–4031.

From foe to friend: using animal toxins to investigate ion channel function. Journal of Molecular Biology (2015) 427, 158– 175.

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery pipeline. British Journal of Pharmacology (2015) 172, 2445–2458.

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop. FEBS Journal (2015) 82, 904–920.

Centipede venom: recent discoveries and current state of knowledge. Toxins (2015) 7, 679–704.

Weaponization of a hormone: convergent recruitment of hyperglycemic hormone into the venom of arthropod predators. Structure (2015) 23, 1283–1292

Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology (2015) 88, 291–303.

Molecular dynamics and functional studies define crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology (2015) 172, 4985–4995.

Widespread convergence in toxin resistance by predictable molecular evolution. Proceedings of the National Academy of Sciences U S A (2015) 112, 11911–11916

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a. Neuropharmacology (2015) 99, 650–657.

Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from the venom of an Australian tarantula. Toxins (2015) 7, 2514–2533.

The cystine knot is responsible for the exceptional stability of the insecticidal spider toxin ω-hexatoxin-Hv1a. Toxins (2015) 7, 4366–4380.

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. Scientific Reports (2015) 5, 14763.

Bacteria may cope differently to similar membrane damage caused by the Australian antimicrobial peptide maculatin 1.1, J Biol Chem, (2015) 290, 19853-19862

Compact, hydrophilic, lanthanide-binding tags for paramagnetic NMR spectroscopy. Chem. Sci. (2015) 6, 2614-2624.

Generation of pseudocontact shifts in proteins with lanthanides using small “clickable” nitrilotriacetic acid and iminodiacetic acid tags. Chem. Eur. J. (2015) 21, 5084-5092.

Capturing conformational states in proteins using sparse paramagnetic NMR data. PLoS ONE, (2015) e0127053.

O-tert- butyltyrosine, an NMR tag for high-molecular weight systems and measurements of submicromolar ligand affinities. J. Am. Chem. Soc. (2015) 137, 4581-4586.

Protein conformation by EPR spectroscopy using gadolinium tags clicked to genetically encoded p-azido-L-phenylalanine. Chem. Commun. (2015) 51, 15898-15901.

Gd3+ spin labeling for measuring distances in biomacromolecules: why and how? Methods Enzymol. (2015) 563, 415-457.

A new Gd3+ spin label for Gd3+-Gd3+ distance measurements in proteins produces narrow distance distributions. J. Phys. Chem. Lett. (2015) 6, 5016-5021

Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles.

Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron. App. Env. Micro. (2015) 81, 2612-24

Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction. Protein Sci. (2015) 24, 1412-1422

Reverse evolution leads to molecular speciation despite functional and active-site convergence. eLife. 2015, e06492.

Genomic and metagenomic surveys of hydrogenase distribution indicate H2 is a widely utilised energy source for microbial growth and survival. ISME J. (2015) 10, 761.

Sequence-structure-function classification of a catalytically diverse oxidoreductase superfamily in mycobacteria. J. Mol. Biol. (2015) 427, 3554-3571.

Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC. PloS One. (2015) 10, e0140219.

Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics, Org. Biomol. Chem. (2015) 13, 2012-2021.

The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis, Mol. BioSyst. (2015) 11, 869-881.

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis, Nature (2015) 521, 105-109.

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products, Nat. Prod. Rep. (2015) 32, 1207-1235.

Sequential cyclization of glycopeptide antibiotic peptides combining an in vitro catalytic cascade of Cytochrome P450 enzymes and the X-domain from peptide biosynthesis, Angew. Chemie Int. Ed. (2015) 54, 15715-15719.

A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics. Chem. Sci. (2015) 6, 923-929.

SimC7 is a novel NAD(P)H-dependent ketoreductase essential for the antibiotic activity of the DNA gyrase inhibitor simocyclinone. J. Mol. Biol. (2015) 2192-2204.

Stereochemistry and mechanism of undecylprodigiosin oxidative carbocyclization to streptorubin B by Rieske oxygenase RedG. J. Am. Chem. Soc. (2015) 137, 7889-7897.

Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nat. Rev. Microbiol. (2015) 13, 509-523.

Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chem Biol (2014) 9, 156-163.

Toxic fingers pick ASIC’s pocket: chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angew Chem (2014) 53, 1017-1020.

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chem Biol (2014) 21, 284-294

Disulfide-rich macrocyclic peptides as templates in drug design. Eur J Med Chem (2014) 77, 248-257.

Semienzymatic cyclization of disulfide-rich peptides using sortase A. J Biol Chem (2014) 289, 6627-6638.

A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs α6/α3β2β3 nicotinic acetylcholine receptors. FASEB J (2014) 28, 1842-1853

Evolutionary origins of a bioactive peptide buried within preproalbumin. Plant Cell (2014) 26, 981-995

Discovery, synthesis and development of structure-activity relationships of conotoxins. Chem Rev (2014) 114, 5815-5847

Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels. Br J Pharmacol (2014) 171, 3313-3327

The chemistry and biology of theta-defensins. Angew Chem (2014) 53, 10612-10623

Fmoc-based synthesis of disulfide-rich cyclic peptides. J Org Chem (2014) 79, 5538-5544

Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Med Chem Lett (2014) 5, 1148-1151

Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds: looking into the mirror for drug design. Angew Chem (2014) 53, 11236-41

Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. J Phys Chem B (2014) 118, 11129-36

Improving on nature: making a cyclic heptapeptide orally bioavailable. Angew Chem (2014) 53, 12059-12063

Structural parameters modulating the cellular uptake of disulfide- rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-I. Eur J Med Chem (2014) 88, 10-18

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients. Proc Natl Acad Sci U S A (2014) 111, 17504-17509

Insights into the molecular flexibility of θ- defensins by NMR relaxation analysis. J Phys Chem B (2014) 118, 14257-14266

Peptide Ligation Chemistry at Selenol Amino Acids J. Pept. Sci. (2014) 20, 64-77

Chemoselective Sulfenylation and Peptide Ligation at Tryptophan Chem. Sci. (2014) 5, 260-266

One-Pot Peptide ligation-Desulfurization at Glutamate. Org Lett. (2014) 16, 290-293

Assessment of Myeloperoxidase Activity by the Conversion of Hydroethidine to 2-Chloroethidium J. Biol. Chem. (2014) 289, 5580-5595

Synthesis of Full Length and Truncated Microcin B17 Analogues as DNA Gyrase Poisons. Org. Biomol. Chem. (2014) 12, 1570-1578.

Total Synthesis of Homogeneous Variants of Hirudin P6: A Post-Translationally Modified Anti-Thrombotic Leech-Derived Protein. Angew. Chem. Int. Ed. (2014) 53, 3947-3951

NMR Characterization of Cooperativity: Fast Ligand Binding Coupled to Slow Protein Dimerization. Chem. Sci. (2014) 5, 2783-2788

Trifluoroethanethiol: An Efficient Additive for One-Pot Ligation-Desulfurization Chemistry. J. Am. Chem. Soc. (2014) 136, 8161-8164.

Site-Selective Solid-Phase Synthesis of a CCR5 Sulfopeptide Library to Interrogate HIV Binding and Entry. ACS Chem. Biol. (2014) 9, 2074-2081

Synthesis and Immunological Evaluation of Self-Adjuvanting MUC1-Macrophage Activating Lipopeptide 2 Conjugate Vaccine Candidates. Chem. Commun. (2014) 50, 10273-10276

Total Synthesis of Polydiscamides B, C, and D via a Convergent Native Chemical Ligation-Oxidation Strategy. Org. Lett. (2014) 16, 4500-4503

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: the N- Terminal Region of CCR3 Bound to CCL11/Eotaxin-1. Structure (2014) 22, 1571–1581

Recent Extensions to Native Chemical Ligation for the Chemical Synthesis of Peptides and Proteins. Curr. Opin. Chem. Biol. (2014) 22, 70-78

Synthesis of Gallinamide A Analogues as Potent Falcipain Inhibitors and Antimalarials. J. Med. Chem. (2014) 57, 10557-10563.

Characterisation of non-classical MHC class I genes in the Tasmanian devil (Sarcophilus harrisii). Immunogenetics (2014) 66, 727-735.

Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours. Evolutionary Applications (2014) 7, 260-265.

Identification of dendritic cells, B cell and T cell subsets in Tasmanian devil lymphoid tissue; evidence for poor immune cell infiltration into devil facial tumors. The Anatomical Record, (2014) 297, 925-938.

Characterisation of major histocompatibility complex class I in the Australian cane toad, Rhinella marina. PloS one, (2014) 9, e102824

The koala immunological toolkit: sequence identification and comparison of key markers of the koala (Phascolarctos cinereus) immune response. Australian journal of zoology, (2014) 62, 195-199.

Development of MHC-linked microsatellite markers in the domestic cat and their use to evaluate MHC diversity in domestic cats, cheetahs, and Gir lions. Journal of Heredity, (2014) 105, 493-505

Hierarchical Assembly of Branched Supramolecular Polymers from (Cyclic Peptide) – Polymer Conjugates. Biomacromolecules, (2014) 15, 4002-4011.

Thiosquaramides: pH switchable anion transporters. Chem Sci (2014) 5, 3617-3626.

Drug Conjugation to Cyclic Peptide-Polymer Self-Assembling Nanotubes. Chem Eur J (2014) 20, 12745-12749.

Investigating the Scope of Pseudoproline Assisted Peptide Cyclisation, Tetrahedron, (2014) 70, 7700-7706.

Cobalt(II), iron(II), zinc(II) and palladium(II) complexes of ditopic 4′-{4-[Bis(2-pyridyl)aminomethyl]phenyl}- 2,2′:6′,2”-terpyridine. Synthetic and X-ray structural studies. CrystEngComm, (2014) 16, 6476 – 6482

Thermal Gating in Lipid Membranes Using Thermoresponsive Cyclic Peptide−Polymer Conjugates. J Am Chem Soc (2014) 136, 8018-8026.

Total synthesis and antimalarial activity of pohlianin C and analogues. Bioorg Med Chem Lett (2014) 24, 2645-2647.

Functional disruption of yeast metacaspase, Mca1, leads to miltefosine resistance and inability to mediate miltefosine-induced apoptotic effects. Fungal Genet Biol (2014) 67, 71-81

Sulfate selective recognition with neutral dipeptide anion receptors in aqueous solution. Chem Eur J (2014) 20, 7373-7380

Mono- and dinucleating Ni(II), Cu(II), Zn(II) and Fe(III) complexes of symmetric and unsymmetric Schiff bases incorporating salicylimine functions- synthetic and structural studies. Polyhedron, (2014) 74, 113-121.

Synthetic transporters for sulfate: a new method for the direct detection of lipid bilayer sulfate transport. Chem Sci (2014)

A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes. Chemical Communications. (2014) 50 8181-4.

Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin. Metallomics. (2014) 6, 2126-33.

Potent heterocyclic ligands for human complement C3a receptor. J Med Chem (2014) 57, 8459-8470.

C5aR and C5L2 in concert balance immunometabolism in adipose tissue. Mol Cell Endocrinol (2014) 382, 325-333.

Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding. Tetrahedron (2014) 70, 7645-7650.

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules. Antimicrob Agents Chemother (2014) 58, 3666-3678.

Pathway selective antagonism of proteinase activated receptor 2. Br J Pharmacol (2014) 171, 4112-4124.

Crystal structure of the dithiol oxidase DsbA enzyme from proteus mirabilis bound non-covalently to an active site peptide ligand. J Biol Chem (2014) 289, 19810-19822.

A molecular basis underpinning the T cell heterogeneity of mucosal associated invariant T cells. J Exp Med (2014) 211, 1585-1600.

Complement C5a receptor facilitates cancer metastasis by altering T cell responses in the metastatic niche. Cancer Research (2014) 74, 3454-3465.

Comparative α-helicity of cyclic pentapeptides in water. Angew Chem Int Edit (2014) 53, 6965-6969.

Constraining cyclic peptides to mimic protein structure motifs. Angew Chem Int Ed (2014) 53, 13020-13041.

T cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature (2014) 509, 361-365.

Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides. J Am Chem Soc (2014) 136, 11914-11917.

Cyclic penta- and hexa- leucine peptides without N-methylation are orally absorbed. ACS Med Chem Lett (2014) 5, 1148–1151

Toxin delivery by the coat protein of an aphid-vectored plant virus provides plant resistance to aphids. Nature Biotechnology (2014) 32, 102–105.

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. Nature Communications (2014) 5, 4350.

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications (2014) 5, 3165.

A tarantula-venom peptide antagonises the TRPA1 nociceptor ion channel by binding to the S1–S4 gating domain. Current Biology (2014) 24, 473–483.

Construction of a hypervirulent and specific mycoinsecticide for locust control. Scientific Reports (2014) 4, 7345

No gain, no pain: NaV1.7 as an analgesic target. ACS Chemical Neuroscience (2014) 5, 749–751.

Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (centipedes). Molecular Biology & Evolution (2014) 31, 2124–2148.

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with ASIC3 and hERG channels via overlapping pharmacophores. Journal of Medicinal Chemistry (2014) 57, 9195–9203.

Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications. Journal of Proteomics (2014) 9, 68–83.

Multifunctional warheads: diversification of the toxin arsenal of centipede venoms via novel multidomain transcripts. Journal of Proteomics (2014) 102, 1–10.

Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders. BMC Genomics (2014) 15, 177.

Spider venomics: implications for drug discovery. Future Medicinal Chemistry (2014) 6, 1699–1714.

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting, ChemBioChem, (2014) 15, 1956-65

Intramolecular binding mode of the C-terminus of E. coli single-stranded DNA binding protein (SSB) determined by nuclear magnetic resonance spectroscopy. Nucleic Acids Res. (2014) 42, 2750-2757.

Binding mode of the activity-modulating C- terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease. FEBS J. (2014) 281, 1517-1533.

Bound or free: interaction of the C-terminal domain of E. coli single-stranded DNA binding protein (SSB) with the tetrameric core of SSB. Biochemistry (2014) 53, 1925-1934

The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI. FEBS Lett. (2014) 588, 2206-2211.

Selective 15N-labeling of the side-chain amide groups of asparagine and glutamine for applications in paramagnetic NMR spectroscopy. J. Biomol. NMR (2014) 59, 251-261.

Fe3+ located in the dinuclear metallo-β-lactamase IMP-1 by pseudocontact shifts. Angew. Chemie Int. Ed. (2014) 53, 14269-14272

Use of OpdA, and organophosphorus hydrolase, prevents lethality in an African green monkey model of acute OP poisoning. Toxicology. (2014) 317, 1- 5.

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization. App. Enviro. Micro. (2014) 80, 4003-4011.

5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis. PLOS One. (2014) 9, e94177

Synthesis of a D-Ring Isomer of Galanthamine via a Radical- Based Smiles Rearrangement Reaction. J. Org. Chem. (2014) 79, 6759-6764.

Enzyme Dynamics and Engineering: One Step at a Time. Chem & Biol. (2014) 21, 1259-1260.

Crystal structure of the mouse interleukin-3 beta-receptor: insights into interleukin-3 binding and receptor activation. Biochem. J. (2014) 463, 393-403.

A Facile Fmoc Solid Phase Synthesis Strategy To Access Epimerization-Prone Biosynthetic Intermediates of Glycopeptide Antibiotics, Org. Lett. (2014) 16, 2454-2457.

The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase, Angew. Chemie Int. Ed. (2014) 53, 8518-8522.

Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis, ChemBioChem (2014) 15, 2719-2728.

Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis, Proteins: Struct., Funct., Bioinf. (2014) 83, 711-721.

Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonisation in stambomycin biosynthesis. J. Antibiot. (2014) 67, 71-76

Genome mining of Streptomyces ambofaciens. J. Ind. Microbiol. Biotechnol. (2014) 41, 251-263

Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chem. Sci. (2014) 5, 86-89.

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways. J. Ind. Microbiol. Biotechnol. (2014) 41, 219-232

A quantitative proteomics-based platform to link natural products to gene clusters and identification of a novel juglomycin-type antibiotic. Chem. Biol. (2014) 21, 707-718.

The future of peptide-based drugs Chem Biol Drug Des (2013) Vol 81, 136-47

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature Nat Prod Rep (2013) 30, 108-160.

Peptides from mamba venoms as pain killers. Angew Chem (2013) 52, 3071-3073

NMR of plant proteins. Prog Nucl Magn Reson Spectrosc (2013) 71, 1-34

Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor. J Med Chem (2013) 56, 3557-3567

The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity. J Biol Chem (2013) 288, 10830-10840.

High-affinity cyclic peptide matriptase inhibitors. J Biol Chem (2013) 288, 13885-96

Design of a cyclotide antagonist of neuropilin-1 and -2 that potently inhibits endothelial cell migration. ACS Chem Biol (2013) 8, 1147-1154

Indentifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J Biol Chem (2013) 288, 34428-34442

Cyclotides as grafting frameworks for protein engineering and drug design applications. Biopolymers: Pept Sci (2013) 100, 480-491

Cyclotide biosynthesis. Curr Opin Chem Biol (2013) 17, 546-554

The discovery and applications of cyclotides, Rudinger Award Lecture. J Pept Sci (2013) 19, 393-407

Design, synthesis and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers: Pept Sci (2013) 100, 519-526.

Mining the genome of Arabidopsis thaliana as a basis for the identification of novel bioactive peptides involved in oxidative stress tolerance. J Exp Bot (2013) 64, 5297-5307

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc Natl Acad Sci U S A (2013) 110, 21183-21188

Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors. J Med Chem (2013) 56, 9655-9663

Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor. J Biol Chem (2013) 288, 36141-36148.

Peptide Ligation-Desulfurization Chemistry at Arginine. ChemBioChem (2013) 4, 559-563

Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1). J. Biol. Chem. (2013) 288, 10024-10034.

Synthesis of Peptides and Glycopeptides with Polyproline II Helical Topology as Potential Antifreeze Molecules. Bioorg. Med. Chem. (2013) 21, 3569-3581

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology (2013) 10, 43

Fragments of the Bacterial Toxin Microcin B17 as Gyrase Poisons, PLoS ONE (2013) 8 e61459

Total Synthesis of Fellutamide B and Deoxy- Fellutamides B, C, and D Marine Drugs (2013) 11, 2382-2397

Sulfopeptide Probes of the CXCR4/CXCL12 Interface Reveal Oligomer-Specific Contacts and Chemokine Allostery ACS Chem. Biol. (2013) 8, 1955-1963.

Synthesis of Homogeneous MUC1 Oligomers via a Bi-Directional Ligation Strategy Org. Biomol. Chem. (2013) 11, 6090-6096.

Chemoselective Ligation-Desulfurization at Aspartate Angew. Chem. Int. Ed. (2013) 52, 9723-9727.

Inhibition Studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) Org. Biomol. Chem. (2013) 11, 8113-8126.

Stereoselective Synthesis of Sialylated Tumor-Associated Glycosylamino Acids Org. Lett. (2013) 15, 5794-5797

Total Synthesis of Erythropoietin through the Development and Exploitation of Enabling Synthetic Technologies. Angew. Chem. Int. Ed. (2013) 52, 505-507.

Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer. Proceedings of the National Academy of Sciences (2013) 110 5103-8

Echidna venom gland transcriptome provides insights into the evolution of monotreme venom. PloS one, (2013) 8, e79092

Does the devil facial tumour produce immunosuppressive cytokines as an immune evasion strategy? Veterinary Immunology and Immunopathology (2013) 153 159-64.

Evolution of a contagious cancer: epigenetic variation in devil facial tumour disease. Proceedings of the Royal Society B (2013) 280, 20121720

Placental lipoprotein lipase (LPL) gene expression in a placentotrophic lizard, Pseudemoia entrecasteauxii. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, (2013) 320 465-470

Characterisation of four major histocompatibility complex class II genes of the koala (Phascolarctos cinereus). Immunogenetics, (2013) 65, 37-46

Low major histocompatibility complex diversity in the Tasmanian devil predates European settlement and may explain susceptibility to disease epidemics. Biology letters, (2013) 9, 20120900

Identification of natural killer cell receptor genes in the genome of the marsupial Tasmanian devil (Sarcophilus harrisii). Immunogenetics, (2013) 65, 25- 35.

Janus Cyclic Peptide – Polymer Nanotubes, Nature Commun (2013) 4, 2780

Selective sorption of actinides by titania nanoparticles covalently functionalised with simple organic ligands. ACS Appl Mater Inter (2013) 5, 11984-11994

Colourimetric and Luminescent Squaramide Based Sensors for Chloride: Hydrogen Bonding vs. Deprotonation. Org Lett (2013) 15, 5638-5641.

Functional Characterization of the Hexose Transporter Hxt13p: An Efflux Pump that Mediates Resistance to Miltefosine in Yeast, Fungal Genet. Biol., (2013) 61, 23-32

Hierarchical assembly of discrete copper(II) metallo-structures from pre-assembled dinuclear (bis-β- diketonato)metallocycles and flexible difunctional co-ligands, Dalton Trans., (2013) 42, 14315-14323.

In vitro activity of miltefosine as a single agent and in combination with either voriconazole or posaconazole against uncommon mold pathogens. J Antimicrob Chemother (2013) 68, 2842-2846

Thermoresponsive cyclic peptide – poly(2-ethyl-2-oxazoline) conjugate nanotubes. Chem. Commun., (2013) 49, 6522-6524

Bis[zinc(II)dipicolylamino]-functionalised peptides as high affinity receptors for pyrophosphate ions in water. (2013) 49, 4824 - 4826

Structure elucidation and control of cyclic peptide-derived nanotube assemblies in solution. Chem. Sci., (2013) 4, 2581-2589.

Fragments of the Bacterial Toxin Microcin B17 as Gyrase Poisons, PLOS One, (2013) 8, e61459.

Tuning Colourimetric Indicator Displacement Assays for Naked-Eye Sensing of Pyrophosphate in Aqueous Media Chem Sci (2013) 4, 1680-1686.

Synchrotron XRF Studies of a Bromine-Labelled Cyclic RGD Peptide Interacting with Individual Tumour Cells. J. Synchrotron Rad., (2013) 20, 226-233.

High-Affinity Sulfate Binding in Aqueous Media by Cyclic Peptides with Thiourea Arms, Chem Commun (2013) 49, 264 – 266.

Multi-shell soft nanotubes from cyclic peptide templates, Adv Mater (2013) 25, 1170 – 1172.

Water Soluble Polymeric Nanotubes from Cyclic Peptide Templates. Chem Eur J (2013) 19, 1955-1961.

Synthesis of Tris-(Azacrown) Ethers for Carboxylic Acid Recognition, Tetrahedron, (2013) 69, 38-42.

Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents. Current Opinion in Chemical Biology. (2013) 17, 158-66.

Tools to study distinct metal pools in biology. Dalton Transactions. (2013) 42, 3210-9.

Histone deacetylase 7 promotes Toll-like receptor 4-dependent pro-inflammatory gene expression in macrophages. J Biol Chem (2013) 288, 25362-25374.

An mRNA atlas of G protein- coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation. Immunobiology (2013) 218, 1345-1353.

C5a, but not C5a-des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2. Immunol Cell Biol (2013) 91, 625-633.

Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1. PLoS One (2013) 8, e59415.

Identification and characterization of bi-thiazole-2,2′-diamines as kinase inhibitory scaffolds. Biochim Biophys Acta (2013) 1834, 1077-1088.

Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases. Acta Cryst D Biol Cryst (2013) 69, 1981–94.

PAR2-induced inflammatory responses in human kidney tubular epithelial cells. Am J Physiol Renal Physiol (2013) 304, F737-750.

An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein. J Gen Virol (2013) 94, 1961-1971.

Efficient chemical synthesis of human complement protein C3a. Chem Commun (2013) 49, 2356-2358.

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism. FASEB J (2013) 27, 4757-67.

C5aR and C3aR antagonists inhibit diet- induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. FASEB J (2013) 27, 822-31.

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal- associated invariant T cells. J Exp Med (2013) 210, 2305-2320

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a. J Immunol (2013) 191, 4308-4316.

Towards drugs for protease-activated receptor 2. J Med Chem (2013) 56, 7477-97.

Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nature Communications (2013) 4, 2142.

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications (2013) 4, 2802.

Discovery of a selective NaV1.7 blocker from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proceedings of the National Academy of Sciences USA (2013) 110, 17534–17539.

Dracula’s children: molecular evolution of vampire bat venom. Journal of Proteomics (2013) 89, 95–111.

Spider-venom peptides: structure, pharmacology, and potential for control of insect pests. Annual Review of Entomology (2013) 58, 475–496.

The insecticidal toxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels. Biochemical Pharmacology (2013) 85, 1542–1554.

Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula. PloS ONE (2013) 8 e73136.

The venom optimization hypothesis revisited. Toxicon (2013) 63, 120–128.

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli. PLoS ONE (2013) 8, e63865.

The insecticidal potential of venom peptides. Cellular & Molecular Life Sciences (2013) 70, 3665–3693.

Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular & Cellular Proteomics (2013) 12, 651–663.

Squeezers and leaf-cutters: differential diversification and degeneration of the venom system in toxicoferan reptiles. Molecular & Cellular Proteomics (2013) 12, 1881–1899

A proteomics and transcriptomics investigation of the venom from the Barychelidae spider Trittame loki (Brush-foot trapdoor). Toxins (2013) 5, 2488–2503.

Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenal. PLoS ONE (2013) 8, e81827.

SVM-based prediction of propeptide cleavage sites in spider toxins identifies toxin innovation in an Australian tarantula. PloS ONE (2013) 8, e66279.

Molecular phylogeny and evolution of the proteins encoded by coleoid (cuttlefish, octopus, squid) posterior venom glands. Journal of Molecular Evolution (2013) 76, 192–204.

Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry. Journal of Proteomics (2013) 80, 292–310.

Aphicidal efficacy of scorpion- and spider- derived neurotoxins. Toxicon (2013) 70, 114–122.

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram- negative and Gram-positive bacteria, BBA-Biomembranes, (2013) 1828, 944-955.

The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability, ChemBioChem, (2013) 14, 2013-2022

A novel quantitative kinase assay using bacterial surface display flow cytometry, PLoS One, (2013) 8, e80474

Synthesis of (±)- panduratin A and related natural products using the high pressure Diels-Alder reaction. Asian J. Org. Chem. (2013) 2, 60-63.

Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins. Bioconjugate Chem. (2013) 24, 260-268.

W-band orientation selective DEER measurements on a Gd3+/nitroxide mixed-labeled protein dimer with a dual mode cavity. J. Magn. Reson. (2013) 227, 66-71

A systematic study of labelling an α-helix in a protein with a lanthanide using IDA or NTA tags. J. Biomol. NMR (2013) 55, 157-166.

Biosynthetically directed 2H labelling for stereospecific resonance assignments of glycine methylene groups. J. Biomol. NMR (2013) 55, 97-104.

3D protein fold determination from pseudocontact shifts of backbone amides. Structure (2013) 21, 883-890.

Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, ε, θ and β reveals a highly flexible arrangement of the proofreading domain. Nucleic Acids Res. (2013) 41, 5354-5367.

In situ deprotection and incorporation of unnatural amino acids during cell-free protein synthesis. Chem. Eur. J. (2013) 19, 6824-6830.

Protein engineering with unnatural amino acids. Curr. Opin. Struct. Biol. (2013) 23, 581-587.

How reliable are pseudocontact shifts induced in proteins and ligands by mobile paramagnetic metal tags? A modelling study. J. Biomol. NMR (2013) 56, 203-216.

Gd3+ spin labels for high sensitivity distance measurements in transmembrane helices. Angew. Chemie Int. Ed. (2013) 52, 11831-11834.

Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance. Proc. Natl. Acad. Sci. U.S.A. (2013) 110, 10177-82.

Ultrafast Charge Rearrangement and Nuclear Dynamics upon Inner-Shell Multiple Ionization of Small Polyatomic Molecules, Phys. Rev. Lett. (2013) 110, 053003/1-053003/5.

Cytochrome P450sky interacts directly with the nonribosomal peptide synthetase to generate three amino acid precursors in skyllamycin biosynthesis, ACS Chem. Biol. (2013) 8, 2586-2596.

Inner-shell multiple ionization of polyatomic molecules with an intense X-ray free-electron laser studied by coincident ion momentum imaging, J. Phys. B (2013) 46, 164031-164112.

Structure and biosynthesis of scabichelin, a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.22. Org. Biomol. Chem. (2013) 11, 4686-4694.

Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases. ACS catalysis, (2013) 3, 2362-2370