Journal Articles

This page contains an overview of relevant publications of centre researchers.

Zwicker,V.E., Yeo,J.H., Fraser,S.T. and Jolliffe,K.A.

Detection of cell-surface phosphatidylserine using the fluorogenic probe P-IID. Meth. Enzymol. (2020) 640, 291-307.

DOI: 10.1016/bs.mie.2020.04.032

Zhang,M.Y. and Malins,L.R.

Decarboxylative Couplings for Late-Stage Peptide Modifications. Methods Mol. Biol. (2020) 2103, 275-285.

DOI: 10.1007/978-1-0716-0227-0_19

Chandler,P.G., Broendum,S.S., Riley,B.T., Spence,M.A., Jackson,C.J. and Buckle,A.M.

Strategies for Increasing Protein Stability. Methods Mol. Biol. (2020) 2073, 163-181.

DOI: 10.1007/978-1-4939-9869-2_10

Yan,J., Allen,S., McDonald,E., Das,I., Mak,J.Y.W., Liu,L., Fairlie,D.P., Meehan,B.S., Chen,Z., Corbett,A.J., Varelias,A. and Teng,M.W.L.

MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1. Cancer Discov (2020) 10, 124-141.

DOI: 10.1158/2159-8290.CD-19-0569

Karas,J.A., Chen,F., Schneider-Futschik,E.K., Kang,Z., Hussein,M., Swarbrick,J., Hoyer,D., Giltrap,A.M., Payne,R.J. and Velkov,T.

Synthesis and structure-activity relationships of teixobactin. Ann. N. Y. Acad. Sci. (2020) 1459, 86-105.

DOI: 10.1111/nyas.14282

Algate,K., Haynes,D., Fitzsimmons,T., Romeo,O., Wagner,F., Holson,E., Reid,R., Fairlie,D. and Cantley,M.

Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. J. Cell. Biochem. (2020) 121, 244-258.

DOI: 10.1002/jcb.29137

Hansen,I.K.Ø., Isaksson,J., Poth,A.G., Hansen,K.Ø., Andersen,A.J.C., Richard,C.S.M., Blencke,H.M., Stensvåg,K. and Haug,T.

Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens. Mar Drugs (2020) 18, 51.

DOI: 10.3390/md18010051

Chisholm,T.S., Kulkarni,S.S., Hossain,K.R., Cornelius,F. and Payne,R.J.

Peptide Ligation at High Dilution via Reductive Diselenide-Selenoester Ligation. J. Am. Chem. Soc. (2020) 142, 1090-1100.

DOI: 10.1021/jacs.9b12558

Chang,C.J., James,T.D. and Tang,B.Z.

Activity-Based Sensing: Achieving Chemical Selectivity through Chemical Reactivity. Acc. Chem. Res. (2020) 53, 1.

DOI: 10.1021/acs.accounts.9b00542

Li,C.Y., Yap,K., Swedberg,J.E. and de Veer,S.J.

Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors. J. Med. Chem. (2020) 63, 816-826.

DOI: 10.1021/acs.jmedchem.9b01811

Lee,B.M., Harold,L.K., Almeida,D.V., Afriat-Jurnou,L., Aung,H.L., Forde,B.M., Hards,K., Pidot,S.J., Ahmed,F.H., Mohamed,A.E., Taylor,M.C., West,N.P., Stinear,T.P., Greening,C., Beatson,S.A., Nuermberger,E.L. and Jackson,C.J.

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathog. (2020) 16, e1008287.

DOI: 10.1371/journal.ppat.1008287

Sorolla,A., Wang,E., Golden,E., Duffy,C., Henriques,S.T. and Blancafort,P.

Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics. Oncogene (2020) 39, 1167-1184.

DOI: 10.1038/s41388-019-1056-3

Wang,X., Corcilius,L. and Payne,R.J.

Synthesis and Utility of β-Selenophenylalanine and β-Selenoleucine in Diselenide-Selenoester Ligation. J. Org. Chem. (2020) 85, 1567-1578.

DOI: 10.1021/acs.joc.9b02665

Zhao,Y., Goode,R.J.A., Schittenhelm,R.B. and Cryle,M.J.

Exploring the Tetracyclization of Teicoplanin Precursor Peptides through Chemoenzymatic Synthesis. J. Org. Chem. (2020) 85, 1537-1547.

DOI: 10.1021/acs.joc.9b02640

Chow,C.Y., Chin,Y.K., Walker,A.A., Guo,S., Blomster,L.V., Ward,M.J., Herzig,V. and King,G.F.

Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel Na_V1.1 Provide Novel Leads for Development of Antiepileptic Drugs. ACS Pharmacol Transl Sci (2020) 3, 119-134.

DOI: 10.1021/acsptsci.9b00079

Bowyer,A.A. and New,E.J.

A fluorescent three-sensor array for heavy metals in environmental water sources. Analyst (2020) 145, 1195-1201.

DOI: 10.1039/c9an02182e

Yin,K., Deuis,J.R., Dekan,Z., Jin,A.H., Alewood,P.F., King,G.F. and Vetter,I.

Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na_V1.7. Biomedicines (2020) 8, 37.

DOI: 10.3390/biomedicines8020037

Sharma,H., Tan,N.K., Trinh,N., Yeo,J.H. and Pfeffer,F.M.

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state. Chem. Commun. (Camb.) (2020) 56, 2240-2243.

DOI: 10.1039/c9cc09748a

Das Gupta,K., Shakespear,M.R., Curson,J.E.B., Murthy,A.M.V., Iyer,A., Hodson,M.P., Ramnath,D., Tillu,V.A., von Pein,J.B., Reid,R.C., Tunny,K., Hohenhaus,D.M., Moradi,S.V., Kelly,G.M., Kobayashi,T., Gunter,J.H., Stevenson,A.J., Xu,W., Luo,L., Jones,A., Johnston,W.A., Blumenthal,A., Alexandrov,K., Collins,B.M., Stow,J.L. and Sweet,M.J.

Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2. Cell Rep (2020) 30, 2712-2728.e8.

DOI: 10.1016/j.celrep.2020.02.007

Xu,P., Kaas,Q., Wu,Y., Zhu,X., Li,X., Harvey,P.J., Zhangsun,D. and Luo,S.

Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA. J. Med. Chem. (2020) 63, 1564-1575.

DOI: 10.1021/acs.jmedchem.9b01409

Yang,X., Mohseni,M., Bas,O., Meinert,C. and Castro,N.J.

Type II Photoinitiator and Tuneable Poly(Ethylene Glycol)-Based Materials Library for Visible Light Photolithography. Tissue Eng Part A (2020) 26, 292-304.

DOI: 10.1089/ten.TEA.2019.0282

Jin,J., Agwa,A.J., Szanto,T.G., Csóti,A., Panyi,G., Schroeder,C.I. and King,G.F.

Weaponisation on the fly: Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies. Insect Biochem. Mol. Biol. (2020) 118, 103310.

DOI: 10.1016/j.ibmb.2019.103310

Deplazes,E., Chin,Y.K. and Mancera,R.L.

The unusual conformation of cross-strand disulfide bonds is critical to the stability of β-hairpin peptides. Proteins (2020) 88, 485-502.

DOI: 10.1002/prot.25828

Gartia,J., Anangi,R., Joshi,R.S., Giri,A.P., King,G.F. and Chary,K.V.R.

NMR structure and dynamics of inhibitory repeat domain variant 12, a plant protease inhibitor from Capsicum annuum, and its structural relationship to other plant protease inhibitors. J. Biomol. Struct. Dyn. (2020) 38, 1388-1397.

DOI: 10.1080/07391102.2019.1607559

Schwartz,B.D., Zhang,M.Y., Attard,R.H. and Malins,L.R.

Structurally Diverse Acyl Bicyclobutanes: Valuable Strained Electrophiles. Chemistry (2020) 26, 2808-2812.

DOI: 10.1002/chem.201905539

Chiorean,S., Antwi,I., Carney,D.W., Kotsogianni,I., Giltrap,A.M., Alexander,F.M., Cochrane,S.A., Payne,R.J., Martin,N.I. and Vederas,J.C.

Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell-Wall Precursor Lipid II. Chembiochem (2020) 21, 789-792.

DOI: 10.1002/cbic.201900504

Zhong,Y., Paudel,B.P., Ryan,D.P., Low,J.K.K., Franck,C., Patel,K., Bedward,M.J., Torrado,M., Payne,R.J. and Mackay,J.P.

CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation. Nat Commun (2020) 11, 1519.

DOI: 10.1038/s41467-020-15183-2

Du,J., Yap,K., Chan,L.Y., Rehm,F.B.H., Looi,F.Y., Poth,A.G., Gilding,E.K., Kaas,Q. and Craik,D.J.

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nat Commun (2020) 11, 1575.

DOI: 10.1038/s41467-020-15418-2

Awad,W., Ler,G.J.M., Xu,W., Keller,A.N., Mak,J.Y.W., Lim,X.Y., Liu,L., Eckle,S.B.G., Le Nours,J., McCluskey,J., Corbett,A.J. and Rossjohn,J.

The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nat. Immunol. (2020) 21, 400-411.

DOI: 10.1038/s41590-020-0616-6

Luna-Ramirez,K., Csoti,A., McArthur,J.R., Chin,Y.K.Y., Anangi,R., Najera,R.D.C., Possani,L.D., King,G.F., Panyi,G., Yu,H. and Finol-Urdaneta,R.K.

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochem. Pharmacol. (2020) 174, 113782.

DOI: 10.1016/j.bcp.2019.113782

Thejer,B.M., Adhikary,P.P., Kaur,A., Teakel,S.L., Van Oosterum,A., Seth,I., Pajic,M., Hannan,K.M., Pavy,M., Poh,P., Jazayeri,J.A., Zaw,T., Pascovici,D., Ludescher,M., Pawlak,M., Cassano,J.C., Turnbull,L., Jazayeri,M., James,A.C., Coorey,C.P., Roberts,T.L., Kinder,S.J., Hannan,R.D., Patrick,E., Molloy,M.P., New,E.J., Fehm,T.N., Neubauer,H., Goldys,E.M. and Cahill,M.A.

PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth. BMC Mol Cell Biol (2020) 21, 24.

DOI: 10.1186/s12860-020-00256-3

Yu,R., Wang,J., So,L.Y., Harvey,P.J., Shi,J., Liang,J., Dou,Q., Li,X., Yan,X., Huang,Y.H., Xu,Q., Kaas,Q., Chow,H.Y., Wong,K.Y., Craik,D.J., Zhang,X.H. and Wang,Y.

Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. J. Med. Chem. (2020) 63, 3475-3484.

DOI: 10.1021/acs.jmedchem.9b01563

Agwa,A.J., Tran,P., Mueller,A., Tran,H.N.T., Deuis,J.R., Israel,M.R., McMahon,K.L., Craik,D.J. and Schroeder,C.I.

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. J. Biol. Chem. (2020) 295, 5067-5080.

DOI: 10.1074/jbc.RA119.012281

Thejer,B.M., Adhikary,P.P., Teakel,S.L., Fang,J., Weston,P.A., Gurusinghe,S., Anwer,A.G., Gosnell,M., Jazayeri,J.A., Ludescher,M., Gray,L.A., Pawlak,M., Wallace,R.H., Pant,S.D., Wong,M., Fischer,T., New,E.J., Fehm,T.N., Neubauer,H., Goldys,E.M., Quinn,J.C. and Cahill,M.A.

PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease. BMC Mol Cell Biol (2020) 21, 26.

DOI: 10.1186/s12860-020-00268-z

Chung,J.H., Tang,A.H., Geraghty,K., Corcilius,L. and Payne,R.J.

Total Synthesis and Antitrypanosomal Activity of Janadolide and Simplified Analogues. Org. Lett. (2020) 22, 3089-3093.

DOI: 10.1021/acs.orglett.0c00840

Smithies,B.J., Huang,Y.H., Jackson,M.A., Yap,K., Gilding,E.K., Harris,K.S. and Craik,D.J.

Circular Permutation of the Native Enzyme-Mediated Cyclization Position in Cyclotides. ACS Chem. Biol. (2020) 15, 962-969.

DOI: 10.1021/acschembio.9b00996

Chow,C.Y., Chin,Y.K.Y., Ma,L., Undheim,E.A.B. and King,G.F.

A selective Na_V1.1 activator with potential for treatment of Dravet syndrome epilepsy. Biochem. Pharmacol. (2020) , 113991.

DOI: 10.1016/j.bcp.2020.113991

Mendoza-Porras,O., Kamath,S., Harris,J.O., Colgrave,M.L., Huerlimann,R. and Wade,N.M.

Resolving hemocyanin isoform complexity in haemolymph of black tiger shrimp Penaeus monodon – implications in aquaculture, medicine and food safety. J Proteomics (2020) 218, 103689.

DOI: 10.1016/j.jprot.2020.103689

Bose,U., Juhász,A., Broadbent,J.A., Byrne,K. and Colgrave,M.L.

Identification and Quantitation of Amylase Trypsin Inhibitors Across Cultivars Representing the Diversity of Bread Wheat. J. Proteome Res. (2020) 19, 2136-2148.

DOI: 10.1021/acs.jproteome.0c00059

Kaniusaite,M., Tailhades,J., Kittilä,T., Fage,C.D., Goode,R.J.A. and Cryle,M.J.

Understanding the early stages of peptide formation during the biosynthesis of teicoplanin and related glycopeptide antibiotics. FEBS J. (2020) In Press.

DOI: 10.1111/febs.15350

Gonzales,J., Pirovano,G., Chow,C.Y., de Souza Franca,P.D., Carter,L.M., Klint,J.K., Guru,N., Lewis,J.S. and Reiner,T.

Fluorescence labeling of a Na_V1.7-targeted peptide for near-infrared nerve visualization. EJNMMI Res (2020) 10, 49.

DOI: 10.1186/s13550-020-00630-4

Du,Q., Chan,L.Y., Gilding,E.K., Henriques,S.T., Condon,N.D., Ravipati,A.S., Kaas,Q. and Craik,D.J.

Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. J. Biol. Chem. (2020) In Press.

DOI: 10.1074/jbc.RA120.012627

Mendoza-Porras,O., Pires,P.R.L., Goswami,H., Meirelles,F.V. and Wijffels,G.

Cytokines in the grass, a lesson learnt: Measuring cytokines in plasma using multiple reaction monitoring mass spectrometry. Rapid Commun. Mass Spectrom. (2020) 34, e8723.

DOI: 10.1002/rcm.8723

Grinter,R., Ney,B., Brammananth,R., Barlow,C.K., Cordero,P.R.F., Gillett,D.L., Izoré,T., Cryle,M.J., Harold,L.K., Cook,G.M., Taiaroa,G., Williamson,D.A., Warden,A.C., Oakeshott,J.G., Taylor,M.C., Crellin,P.K., Jackson,C.J., Schittenhelm,R.B. and Greening,C.

Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F₄₂₀-0 in Mycobacteria. mSystems (2020) 5, In Press.

DOI: 10.1128/mSystems.00389-20

Adair,L.D., Trinh,N., Vérité,P.M., Jacquemin,D. and New,E.J.

Synthesis of Nitro-Aryl Functionalised 4-Amino-1,8-Naphthalimides and Their Evaluation as Fluorescent Hypoxia Sensors. Chemistry (2020) In Press.

DOI: 10.1002/chem.202002088

Bose,U., Broadbent,J.A., Byrne,K., Blundell,M.J. and Colgrave,M.L.

Proteome Analysis of Hordein-Null Barley Lines Reveals Storage Protein Synthesis and Compensation Mechanisms. J. Agric. Food Chem. (2020) 68, 5763-5775.

DOI: 10.1021/acs.jafc.0c01410

Johansen-Leete,J., Passioura,T., Foster,S.R., Bhusal,R.P., Ford,D.J., Liu,M., Jongkees,S.A.K., Suga,H. and Payne,R.J.

Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display. J. Am. Chem. Soc. (2020) 142, 9141-9146.

DOI: 10.1021/jacs.0c03152

Chow,C.Y., Absalom,N., Biggs,K. and Ma,L.

Venom-derived modulators of epilepsy-related ion channels. Biochem. Pharmacol. (2020) , 114043.

DOI: 10.1016/j.bcp.2020.114043

Pineda,S.S., Chin,Y.K., Undheim,E.A.B., Senff,S., Mobli,M., Dauly,C., Escoubas,P., Nicholson,G.M., Kaas,Q., Guo,S., Herzig,V. and King,G.F.

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene. Proc. Natl. Acad. Sci. U.S.A. (2020) 117, 11399-11408.

DOI: 10.1073/pnas.1914536117

Zhu,J., Yeo,J.H., Bowyer,A.A. and New,E.J.

Studies of the labile lead pool using a rhodamine-based fluorescent probe. Metallomics (2020) 12, 644-648.

DOI: 10.1039/d0mt00056f

Boulouis,C., Sia,W.R., Gulam,M.Y., Teo,J.Q.M., Png,Y.T., Phan,T.K., Mak,J.Y.W., Fairlie,D.P., Poon,I.K.H., Koh,T.H., Bergman,P., Lim,C.M., Wang,L.F., Kwa,A.L.H. and Leeansyah,E.

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli. PLoS Biol. (2020) 18, e3000644.

DOI: 10.1371/journal.pbio.3000644

Rupasinghe,D.B., Herzig,V., Vetter,I., Dekan,Z., Gilchrist,J., Bosmans,F., Alewood,P.F. and King,G.F.

Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na_V1.7. Biochem. Pharmacol. (2020) , 114080.

DOI: 10.1016/j.bcp.2020.114080

Franck,C., Foster,S.R., Johansen-Leete,J., Chowdhury,S., Cielesh,M., Bhusal,R.P., Mackay,J.P., Larance,M. and Payne,R.J.

Semisynthesis of an evasin from tick saliva reveals a critical role of tyrosine sulfation for chemokine binding and inhibition. Proc. Natl. Acad. Sci. U.S.A. (2020) 117, 12657-12664.

DOI: 10.1073/pnas.2000605117

Israel,M.R., Dash,T.S., Bothe,S.N., Robinson,S.D., Deuis,J.R., Craik,D.J., Lampert,A. and Durek,T.

Characterization of Synthetic Tf2 as a Na_V1.3 Selective Pharmacological Probe. Biomedicines (2020) 8, 155.

DOI: 10.3390/biomedicines8060155

Tng,J., Lim,J., Wu,K.C., Lucke,A.J., Xu,W. and Fairlie,D.P.

Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation. J. Med. Chem. (2020) 63, 5956-5971.

DOI: 10.1021/acs.jmedchem.0c00230

Herzig,V., Cristofori-Armstrong,B., Israel,M.R., Nixon,S.A. and King,G.F.

Animal toxins – Natures evolutionary-refined toolkit for basic research and drug discovery. Biochem. Pharmacol. (2020) , 114096.

DOI: 10.1016/j.bcp.2020.114096

Yin,H., Huang,Y.H., Deprey,K., Condon,N.D., Kritzer,J.A. and Wang,C.K.

Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold. ACS Chem. Biol. (2020) 15, 1650-1661.

DOI: 10.1021/acschembio.0c00297

Hawkins,P., Tran,W., Nagalingam,G., Cheung,C.Y., Giltrap,A., Cook,G. and Payne,R.J.

Total Synthesis and Antimycobacterial Activity of Ohmyungsamycin A, Deoxyecumicin, and Ecumicin. Chemistry (2020) In Press.

DOI: 10.1002/chem.202002408

Huynh,P.N., Harvey,P.J., Gajewiak,J. and Michael McIntosh,J.

Critical Residue Properties for Potency and Selectivity of α-Conotoxin RgIA Towards α9α10 Nicotinic Acetylcholine Receptors. Biochem. Pharmacol. (2020) , 114124.

DOI: 10.1016/j.bcp.2020.114124

Dang,T.T., Chan,L.Y., Huang,Y.H., Nguyen,L.T.T., Kaas,Q. and Craik,D.J.

Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species. J. Nat. Prod. (2020) 83, 1817-1828.

DOI: 10.1021/acs.jnatprod.9b01218

Tailhades,J., Zhao,Y., Ho,Y.T.C., Greule,A., Ahmed,I., Schoppet,M., Kulkarni,K., Goode,R.J.A., Schittenhelm,R.B. and Cryle,M.J.

A Chemoenzymatic Approach to the Synthesis of Glycopeptide Antibiotic Analogues. Angew. Chem. Int. Ed. Engl. (2020) 59, 10899-10903.

DOI: 10.1002/anie.202003726

de Veer,S.J. and Craik,D.

Sunflower Trypsin Inhibitor-1 (SFTI-1): Sowing Seeds in the Fields of Chemistry and Biology. Angew. Chem. Int. Ed. Engl. (2020) In Press.

DOI: 10.1002/anie.202006919

White,A.M., de Veer,S.J., Wu,G., Harvey,P.J., Yap,K., King,G.J., Swedberg,J.E., Wang,C.K., Law,R.H.P. and Craik,D.J.

Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. Angew. Chem. Int. Ed. Engl. (2020) 59, 11273-11277.

DOI: 10.1002/anie.202003435

Tombling,B.J. and Craik,D.J.

EGF-like and Other Disulfide-rich Microdomains as Therapeutic Scaffolds. Angew. Chem. Int. Ed. Engl. (2020) 59, 11218-11232.

DOI: 10.1002/anie.201913809

Stanley, C. P.; Maghzal, G. J.; Ayer, A.; Talib, J.; Giltrap, A. M.; Shengule, S.; Wang, Y.; Chadha, P.; Suarna, C.; Prysyazhna, O.; Scotcher, J.; Dunn, L. L.; Prado, F. M.; Smith, N.; Nguyen, N.; Odiba, J. O.; Baell, J. B.; Graham, R.; Stasch, J-P.; Yamamoto, Y.; Di Mascio, P.; Eaton, P.; Payne, R. J.; Stocker, R.

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation Nature (2019) 566 548–552

DOI: 10.1038/s41586-019-0947-3

Thorn, D. C., Grosas, A. B., Mabbitt, P. D., Ray, N. J., Jackson, C. J., Carver, J. C.

The structure and stability of the disulfide-linked γS-crystallin dimer provide insight into oxidation products associated with lens cataract formation. J. Mol. Biol. (2019) 431, 483-497

DOI: 10.1016/j.jmb.2018.12.005

S. Heidarian, F. Mohammadipanah, A. Maghsoudlou, Y. Dashti and G.L. Challis.

Anti-microfouling activity of Glycomyces sediminimaris UTMC 2460 on dominant fouling bacteria of Iran marine habitats. Front. Microbiol. (2019) 9, 3148

DOI: 10.3389/fmicb.2018.03148

Grueber, C.E., Fox, S., McLennan, E.A., Gooley, R.M., Pemberton, D., Hogg, C.J., & Belov, K.,

Complex problems need detailed solutions: harnessing multiple data types to inform genetic management in the wild. Evolutionary Application (2019) 12, 280–291

DOI: 10.1111/eva.12715

V. E. Zwicker, B. L. Oliveira, J. H. Yeo, S. T. Fraser, G. J. L. Bernardes, E. J. New and K. A. Jolliffe,

A fluorogenic probe for cell surface phosphatidylserine using an intramolecular indicator displacement sensing mechanism. Angew Chem Int Ed (2019) 58, 3087-3091

DOI: 10.1002/anie.201812489

Smith, D. G., Mitchell, L., New, E.J.,

Pattern recognition of toxic metal ions using a single-probe thiocoumarin array. Analyst, (2019) 144, 230-236.

DOI: 10.1039/c8an01747f

Fleming, C. L., Natoli, A., Schreuders, J., Devlin, M., Yoganantharah, P., Gilbert, Y., Leslie, K. G., New, E. J., Ashton, T. D., Pfeffer, F. M.,

Highly fluorescent and HDAC6 selective scriptaid analogues. European Journal of Medicinal Chemistry, (2019) 162, 321-333

DOI: 10.1016/j.ejmech.2018.11.020

Chambers C, Cutler P, Huang YH, Goodchild JA, Blythe J, Wang CK, Bigot A, Kaas Q, Craik DJ, Sabbadin D, Earley FG.

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. FEBS Lett. (2019)

DOI: 10.1002/1873-3468.13435

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Bende N, Dziemborowicz S, Mobli M, Herzig V, Gilchrist J, Nicholson GM, King GF* & Bosmans F*

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. Nature Communications (2014) 5, 4350.

DOI: 10.1038/ncomms5350

de Araujo AD, Mobli M, Brierley SM, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King GF, Brierley SM* & Alewood PF*

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications (2014) 5, 3165.

DOI: 10.1038/ncomms4165

Gui J, Liu B, Cao G... Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE & Nitabach MN

A tarantula-venom peptide antagonises the TRPA1 nociceptor ion channel by binding to the S1–S4 gating domain. Current Biology (2014) 24, 473–483.

DOI: 10.1016/j.cub.2014.01.013

Fang W, Lu HL, King GF & St Leger RJ

Construction of a hypervirulent and specific mycoinsecticide for locust control. Scientific Reports (2014) 4, 7345

DOI: 10.1038/srep07345

King GF & Vetter I

No gain, no pain: NaV1.7 as an analgesic target. ACS Chemical Neuroscience (2014) 5, 749–751.

DOI: 10.1021/cn500171p

Undheim EAB, Jones A, Holland JW, Clauser K, Pineda SS, King GF & Fry BG

Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (centipedes). Molecular Biology & Evolution (2014) 31, 2124–2148.

DOI: 10.1093/molbev/msu162

Jensen JE, Cristofori-Armstrong B, Anangi R, Rosengren KJ, Lau CHY, Mobli M, Brust A, Alewood PF, King GF & Rash LD

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with ASIC3 and hERG channels via overlapping pharmacophores. Journal of Medicinal Chemistry (2014) 57, 9195–9203.

DOI: 10.1021/jm501400p

Sunagar K, Undheim EAB, Scheib H, Gren ECK, Cochran C, Person CE, Koludarov I, Kelln W, Hayes WK, King GF, Antunes A & Fry BG*

Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications. Journal of Proteomics (2014) 9, 68–83.

DOI: 10.1016/j.jprot.2014.01.013

Undheim EAB, Sunagar K, Hamilton BR, Jones A, Venter DJ, Fry BG & King GF

Multifunctional warheads: diversification of the toxin arsenal of centipede venoms via novel multidomain transcripts. Journal of Proteomics (2014) 102, 1–10.

DOI: 10.1016/j.jprot.2014.02.024

Pineda SS, Sollod BL, Wilson D, Darling A, Sunagar K, Undheim EAB, Kely L, Antunes A, Fry BG & King GF*

Diversification of a single ancestral gene into a successful toxin superfamily in highly venomous Australian funnel-web spiders. BMC Genomics (2014) 15, 177.

DOI: 10.1186/1471-2164-15-177

Pineda SS*, Undheim EAB, Rupasinghe DB, Ikonomopoulou MP & King GF

Spider venomics: implications for drug discovery. Future Medicinal Chemistry (2014) 6, 1699–1714.

DOI: 10.4155/fmc.14.103

Henriques S.T.,1 Huang Y.H., Chaousis S., Wang C.K., Craik D.J.

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting, ChemBioChem, (2014) 15, 1956-65

DOI: 10.1002/cbic.201402144

Shishmarev, D., Wang, Y., Mason, C. E., Su, X.-C., Oakley, A. J., Graham, B., Huber, T., Dixon, N. E., Otting, G.

Intramolecular binding mode of the C-terminus of E. coli single-stranded DNA binding protein (SSB) determined by nuclear magnetic resonance spectroscopy. Nucleic Acids Res. (2014) 42, 2750-2757.

DOI: 10.1093/nar/gkt1238

de la Cruz, L., Chen, W.-N., Graham, B., Otting, G.

Binding mode of the activity-modulating C- terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease. FEBS J. (2014) 281, 1517-1533.

DOI: 10.1111/febs.12729

Su, X.-C., Wang, Y., Yagi, H., Shishmarev, D., Mason, C. E., Smith, P. J., Vandevenne, M., Dixon, N. E., Otting, G.

Bound or free: interaction of the C-terminal domain of E. coli single-stranded DNA binding protein (SSB) with the tetrameric core of SSB. Biochemistry (2014) 53, 1925-1934

DOI: 10.1021/bi5001867

Chen, W.-N., Loscha, K. V., Nitsche, C., Graham, B., Otting, G.

The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI. FEBS Lett. (2014) 588, 2206-2211.

DOI: 10.1016/j.febslet.2014.05.018

Cao, C., Chen, J.-L., Huang, F., Otting, G., Su, X.-C.

Selective 15N-labeling of the side-chain amide groups of asparagine and glutamine for applications in paramagnetic NMR spectroscopy. J. Biomol. NMR (2014) 59, 251-261.

DOI: 10.1007/s10858-014-9844-0

Carruthers, T. J., Carr, P. D., Loh, C.-T., Jackson, C. J., Otting, G.

Fe3+ located in the dinuclear metallo-β-lactamase IMP-1 by pseudocontact shifts. Angew. Chemie Int. Ed. (2014) 53, 14269-14272

DOI: 10.1002/anie.201408693

Jackson, C.J., Carville, A., Ward, J., Mansfield, K., Ollis, D.L., Bird, S.B.

Use of OpdA, and organophosphorus hydrolase, prevents lethality in an African green monkey model of acute OP poisoning. Toxicology. (2014) 317, 1- 5.

DOI: 10.1016/j.tox.2014.01.003

Jackson, C.J., Coppin, C.W., Carr, P.D., Aleksandrov, A., Wilding, M., Sugrue, E., Ubels, J., Paks, M., Newman, J., Peat, T.S., Russell, R.J., Field, M., Weik, M., Oakeshott, J.G., Scott, C.

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization. App. Enviro. Micro. (2014) 80, 4003-4011.

DOI: 10.1128/AEM.00916-14

Naqvi, T., Warden, A.C., French, N., Sugrue, E., Carr, P.D., Jackson, C.J., Scott, C.

5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis. PLOS One. (2014) 9, e94177

DOI: 10.1371/journal.pone.0094177

Lan, P., Jackson, C.J., Banwell, M.G., Willis, A.C.

Synthesis of a D-Ring Isomer of Galanthamine via a Radical- Based Smiles Rearrangement Reaction. J. Org. Chem. (2014) 79, 6759-6764.

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Tokuriki, N., Jackson, C.J.

Enzyme Dynamics and Engineering: One Step at a Time. Chem & Biol. (2014) 21