Mathias is working on understanding the relationship between structure
and function in enzymes involved in glycopeptide antibiotics (GPAs)
biosynthesis, and how these enzymes evolve to select new substrates. By studying the evolution of
substrate specificity within the conserved structural fold of these enzymes, we
may uncover the template for their efficient reengineering to create novel
GPAs. Outside of the lab, Mathias enjoys bouldering and urban gardening.