NMR and EPR methods for localising peptide ligands on proteins

Lead Chief Investigator: Gottfried Otting, The Australian National University

Collaborating Chief Investigator: Richard Payne



Single-crystal X-ray structures present the gold-standard of structure determination of protein-ligand complexes but critically depend on the availability of single crystals and their capacity to diffract in the X-ray beam. In this project, new NMR and EPR methods are sought to identify the binding site of a high-affinity peptide ligand on its target protein.


Relevance to the Centre

This project aligns with the Centre’s aim to decode the function of peptides.